SK-N-FIHomo sapiens (Human)Cancer cell line

Also known as: SKNF1, SK-N-F1, SKNFI, SK_N_FI, SN-N-FI

🤖 AI SummaryBased on 15 publications

Quick Overview

SK-N-FI is a human neuroblastoma cell line used in cancer research.

Detailed Summary

SK-N-FI is a human neuroblastoma cell line derived from a tumor, commonly used in research to study the molecular mechanisms of neuroblastoma. It is utilized in various studies focusing on genetic alterations, such as MYCN amplification and other genomic changes associated with neuroblastoma progression. This cell line is valuable for investigating the role of specific genes and pathways in tumor development and for testing potential therapeutic strategies.
Generated on 6/17/2025

Basic Information

Database IDCVCL_1702
SpeciesHomo sapiens (Human)
Tissue SourceBone marrow[UBERON:UBERON_0002371]

Donor Information

Age11
Age CategoryPediatric
SexMale
Racecaucasian

Disease Information

DiseaseNeuroblastoma
LineagePeripheral Nervous System
SubtypeNeuroblastoma
OncoTree CodeNBL

DepMap Information

Source TypeATCC
Source IDACH-000341_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Met246Arg (c.737T>G)Homozygous-from parent cell line SK-N-FI
MutationUnexplicitNF1Partial deletionHomozygous-from parent cell line SK-N-FI

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
10,12
D13S317
11,14
D16S539
11,12
D18S51
12,14
D19S433
12
D21S11
28,30
D2S1338
17,18
D3S1358
16,18
D5S818
12,13
D7S820
8,9
D8S1179
11,12
FGA
22
Penta D
2.2,13
Penta E
11,20
TH01
6,9.3
TPOX
8,9
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

ATRX in-frame fusion neuroblastoma is sensitive to EZH2 inhibition via modulation of neuronal gene signatures.

Segura M.F., Dyer M.A., Bernstein E.

Cancer Cell 36:512-527.e9(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.

Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.

Sci. Data 4:170033-170033(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.

Lau L.M.S.

J. Neurooncol. 119:17-26(2014).

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.

Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.

Nat. Genet. 45:12-17(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.

Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.

Int. J. Cancer 131:1556-1568(2012).

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

Messiaen L.M., Versteeg R., Bernards R.

Cell 142:218-229(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Identification of ALK as a major familial neuroblastoma predisposition gene.

Maris J.M.

Nature 455:930-935(2008).

Mutations in PIK3CA are infrequent in neuroblastoma.";

Dam V., Morgan B.T., Mazanek P., Hogarty M.D.

BMC Cancer 6:177.1-177.10(2006).

High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.

Maris J.M.

Genes Chromosomes Cancer 43:390-403(2005).

Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.

Gabbert H.E., Poremba C.

Cancer Res. 64:3395-3405(2004).

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.

Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.

Genes Chromosomes Cancer 32:126-135(2001).

Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.

Speleman F., Versteeg R.

Oncogene 10:291-297(1995).

Determination of cell surface membrane antigens common to both human neuroblastoma and leukemia-lymphoma cell lines by a panel of 38 monoclonal antibodies.

Minowada J.

J. Natl. Cancer Inst. 73:51-57(1984).

Human neuroblastoma cells and 13-cis-retinoic acid.";

Helson L., Helson C.

J. Neurooncol. 3:39-41(1985).

Vitamin E and human neuroblastoma.";

Helson L., Verma M., Helson C.

(In book chapter) Modulation and mediation of cancer by vitamins; Meyskens F.L., Prasad K.N. (eds.); pp.258-265; Karger; Basel; Switzerland (1983).

Tumor cell lines of the peripheral nervous system.";

Israel M.A., Thiele C.J.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).

Web Resources