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SK-PN-DWHomo sapiens (Human)Cancer cell line

Also known as: SKPNDW

🤖 AI SummaryBased on 7 publications

Quick Overview

Human neuroblastoma cell line with unique genetic features for cancer research.

Detailed Summary

The SK-PN-DW cell line, derived from a primitive neuroectodermal tumor, is a valuable resource for studying pediatric cancers. It exhibits complex chromosomal abnormalities, including losses of chromosomes 11, 13, and 18, and a characteristic translocation between chromosomes 11 and 22, commonly associated with Ewing sarcoma. These genetic alterations make it a relevant model for investigating tumor biology and therapeutic targets. The cell line has been used in studies focusing on oncogene mutations, chromosomal instability, and drug response, contributing to understanding the molecular mechanisms of neuroectodermal tumors. Its cytogenetic profile highlights the importance of genetic diversity in cancer research and the need for accurate cell line authentication.

Research Applications

Cancer geneticsOncogene mutation profilingChromosomal instability studiesDrug response and resistanceTumor biology and therapeutic target identification

Key Characteristics

Loss of chromosomes 11, 13, and 18Translocation between chromosomes 11 and 22Complex chromosomal rearrangementsDouble minutes (DMs) observedHigh genetic instability

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1703
Species	Homo sapiens (Human)
Tissue Source	Retroperitoneal space[UBERON:UBERON_0003693]

Donor Information

Age	17
Age Category	Pediatric
Sex	Male
Subtype Features	EWS-FLI

Disease Information

Disease	Primitive neuroectodermal tumor
Lineage	Bone
Subtype	Ewing Sarcoma
OncoTree Code	ES

DepMap Information

Source Type	Academic lab
Source ID	ACH-001193_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys176Phe (c.527G>T)	Unspecified	-	PubMed=8221663
MutationSimple	RB1	p.Trp78Ter (c.234G>A)	Homozygous	-	Unknown, Unknown
Gene fusion	EWSR1	EWSR1-FLI1, EWS-FLI1	-	Type 1 fusion	PubMed=15150091

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

12

D13S317

9

D16S539

12

D18S51

16

D19S433

12,13

D21S11

29,31

D2S1338

17,25

D3S1358

14,16

D5S818

13,14

D7S820

8,14

D8S1179

13,15

FGA

19,22

Penta D

10,11

Penta E

14,16

TH01

6

TPOX

8,9

vWA

16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Cytogenetic characterization of the malignant primitive neuroectodermal SK-PN-DW tumor cell line.

Liu G.-M., Wang F.

BMC Cancer 19:412.1-412.12(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.

Borsu L., Barr F.G., Ladanyi M.

Clin. Cancer Res. 18:748-757(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.

Nycum L.M., Emanuel B.S., Evans G.A.

J. Clin. Invest. 94:489-496(1994).

Primitive neuroectodermal tumor cell lines: chromosomal analysis of five cases.

Potluri V.R., Gilbert F., Helsen C., Helson L.

Cancer Genet. Cytogenet. 24:75-86(1987).

Human neuroblastoma cells and 13-cis-retinoic acid.";

Helson L., Helson C.

J. Neurooncol. 3:39-41(1985).

Systematic multi-omics profiling of Ewing sarcoma cell lines.";

Orth M.F.

Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany.

Tumor cell lines of the peripheral nervous system.";

Israel M.A., Thiele C.J.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).

Web Resources