SKG-IIIaHomo sapiens (Human)Cancer cell line

Also known as: SKG3a, SKG3A, SKG-3a, SKGIIIA, SKG IIIa, SKG-IIIA

🤖 AI SummaryBased on 3 publications

Quick Overview

Human cervical cancer cell line with distinct morphological features.

Detailed Summary

SKG-IIIa is a human cervical cancer cell line derived from a single donor, exhibiting unique morphological characteristics. It is notable for its clear cell features, which are typically associated with adenocarcinoma, and differs significantly from squamous cell carcinoma (SCC) cell lines. The cell line shows upregulation of specific genes such as insulin-like growth factor-binding protein-3 (IGFBP3), inhibitor of apoptosis protein 1 (IAP), and cadherin-13, which are more frequently expressed in SCC. Additionally, it has been used in studies to compare gene expression profiles between different histological types of cervical cancer, contributing to the understanding of molecular differences in carcinogenesis. SKG-IIIa is also part of larger studies examining genetic diversity and ancestry in cancer cell lines, highlighting the importance of considering ancestral backgrounds in cancer research.

Research Applications

Gene expression profiling in cervical cancerComparison of histological types in cervical carcinomaAnalysis of genetic diversity and ancestry in cancer cell lines

Key Characteristics

Distinct morphological features compared to SCCUpregulation of specific genes associated with SCCUsed in studies on molecular differences in carcinogenesis

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1704
Species	Homo sapiens (Human)
Tissue Source	Uterus, cervix[UBERON:UBERON_0000002]

Donor Information

Age	38
Age Category	Adult
Sex	Female

Disease Information

Disease	Squamous cell carcinoma of the cervix uteri
Lineage	Cervix
Subtype	Cervical Squamous Cell Carcinoma
OncoTree Code	CESC

DepMap Information

Source Type	RIKEN
Source ID	ACH-002020_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Lys132Asn (c.396G>C)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

D16S539

9,11

D18S51

D19S433

D21S11

31.2,32.2

D2S1338

19,26

D3S1358

D5S818

10,11

D7S820

D8S1179

11,15

FGA

21,22

Penta D

Penta E

TH01

6,9

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Establishment, authenticity, and characterization of cervical cancer cell lines.

Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.

Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Gene expression profiling in two morphologically different uterine cervical carcinoma cell lines derived from a single donor using a human cancer cDNA array.

Kudo R.

Gynecol. Oncol. 93:446-453(2004).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

Correlation between HPV positivity and state of the p53 gene in cervical carcinoma cell lines.

Fukuyama K., Hori K., Sugimori H.

Gynecol. Oncol. 48:104-109(1993).

DOI PubMed

Biological properties of two newly established cell lines (SKG-3a,3b) from a human uterine cervical epidermoid carcinoma.

Udagawa Y., Nozawa S., Tsukazaki K., Ohta H., Akiba T., Kurihara S.

Nihon Sanka Fujinka Gakkai Zasshi 36:237-246(1984).

PubMed

Newly established uterine cervical cancer cell line (SKG-III) with Regan isoenzyme, human chorionic gonadotropin beta-subunit, and pregnancy-specific beta 1-glycoprotein phenotypes.

Nozawa S., Udagawa Y., Ohta H., Kurihara S., Fishman W.H.

Cancer Res. 43:1748-1760(1983).

PubMed