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SNG-MHomo sapiens (Human)Cancer cell line

Also known as: SNGM

🤖 AI SummaryBased on 10 publications

Quick Overview

Human endometrial cancer cell line with potential for research in tumor biology and drug development.

Detailed Summary

The SNG-M cell line is a human endometrial cancer cell line derived from a poorly differentiated carcinoma. It is used in research to study tumor invasion and the molecular mechanisms underlying cancer progression. This cell line has been characterized for its expression of matrix metalloproteinases (MMPs) and plasminogen activators, which are involved in tumor invasion and metastasis. SNG-M has been utilized in three-dimensional culture systems to investigate interactions between cancer cells and stromal cells, providing insights into the tumor microenvironment. Additionally, it has been used to evaluate the effects of various treatments on tumor growth and to identify potential therapeutic targets.

Research Applications

Tumor invasion and metastasisMolecular mechanisms of cancer progressionDrug development and therapeutic target identificationTumor microenvironment studies

Key Characteristics

Expression of matrix metalloproteinases (MMPs)Plasminogen activator expressionThree-dimensional culture compatibilityPotential for in vivo tumor modeling

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1707
Species	Homo sapiens (Human)
Tissue Source	Obturator lymph node[UBERON:UBERON_0035171]

Donor Information

Age	52
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000974_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	PIK3CA	p.Arg88Gln (c.263G>A)	Heterozygous	-	Unknown, Unknown
MutationSimple	KRAS	p.Gly12Val (c.35G>T)	Heterozygous	Acquired	Unknown, Unknown
MutationSimple	B2M	p.Thr93fs*2 (c.276_277insC)	Heterozygous	-	Unknown, Unknown
MutationSimple	B2M	p.Tyr46fs*10 (c.136_137delTA)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11,12

D13S317

8,10,11

D16S539

10,11,12

D18S51

12,18,19

D19S433

13.2,14,15

D21S11

29,30

D2S1338

19,24,25

D3S1358

13,14,15

D5S818

9,13

D7S820

10,11

D8S1179

11,13

FGA

22

Penta D

8,11

Penta E

11,14

TH01

6,7

TPOX

8,9

vWA

16,17,18,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Three-dimensional coculture of endometrial cancer cells and fibroblasts in human placenta derived collagen sponges and expression matrix metalloproteinases in these cells.

Tanaka R., Saito T., Ashihara K., Nishimura M., Mizumoto H., Kudo R.

Gynecol. Oncol. 90:297-304(2003).

Tumor angiogenesis factors produced by cancer cells.";

Ishiwata I., Sudo T., Kiguchi K., Ishikawa H.

Hum. Cell 12:37-46(1999).

Tissue reconstruction of gynecologic tumor cells in the rotation culture system.

Hashimoto H., Tachibana T., Ishikawa H., Nozawa S.

Hum. Cell 10:175-181(1997).

Tumor angiogenic activity of gynecologic tumor cell lines on the chorioallantoic membrane.

Ishiwata I., Ishiwata C., Soma M., Ono I., Nakaguchi T., Ishikawa H.

Gynecol. Oncol. 29:87-93(1988).

CA125 production by gynecologic tumors in vitro and its modulation induced by dibutyl cyclic adenosine monophosphate.

Ishiwata I., Ishiwata C., Nozawa S., Ishikawa H.

Asia Oceania J. Obstet. Gynaecol. 12:285-290(1986).

Development and characterization of established cell lines from primary and metastatic regions of human endometrial adenocarcinoma.

Ishiwata I., Nozawa S., Inoue T., Okumura H.

Cancer Res. 37:1777-1785(1977).

Web Resources

iclac.org tcpaportal.org