SNU-C2AHomo sapiens (Human)Cancer cell line

Also known as: C2A, NCI-SNU-C2A, SNUC2A, SUN-C2A (Occasionally.)

🤖 AI SummaryBased on 7 publications

Quick Overview

Human colorectal cancer cell line with known mutations and drug sensitivity profiles.

Detailed Summary

SNU-C2A is a human colorectal cancer cell line derived from a patient with colorectal cancer. It is widely used in cancer research to study molecular mechanisms, drug responses, and genetic mutations associated with cancer progression. The cell line has been characterized for its genetic profile, including mutations in key oncogenes and tumor suppressor genes, which contribute to its tumorigenic potential. SNU-C2A is also utilized in studies investigating the efficacy of targeted therapies and chemotherapeutic agents, providing insights into potential treatment strategies for colorectal cancer. Its availability in various research databases makes it a valuable resource for preclinical studies.

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1709
Species	Homo sapiens (Human)
Tissue Source	Cecum[UBERON:UBERON_0001153]

Donor Information

Age	43
Age Category	Adult
Sex	Female
Race	asian
Subtype Features	MSI

Disease Information

Disease	Cecum adenocarcinoma
Lineage	Bowel
Subtype	Colon Adenocarcinoma
OncoTree Code	COAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000967_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273His (c.818G>A)	Homozygous	-	Unknown, PubMed=16264262
MutationSimple	TP53	p.Arg273Cys (c.817C>T)	Homozygous	-	PubMed=35933914
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,14

D13S317

9,12

D16S539

8,9

D18S51

15,16

D19S433

D21S11

D2S1338

D3S1358

D5S818

8,9

D7S820

13,16

D8S1179

11,13

FGA

20,22

Penta D

Penta E

12,19

TH01

TPOX

vWA

15,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Biology of SNU cell lines.";

Ku J.-L., Park J.-G.

Cancer Res. Treat. 37:1-19(2005).

DOI PubMed PMC

Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.

Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.

Eur. J. Cancer 35:1724-1729(1999).

DOI PubMed

Biology of colorectal and gastric cancer cell lines.";

Park J.-G., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:131-141(1996).

DOI PubMed

Characteristics of cell lines established from human colorectal carcinoma.

Johnson B.E., Gazdar A.F.

Cancer Res. 47:6710-6718(1987).

PubMed