SUP-T1Homo sapiens (Human)Cancer cell line

Also known as: Sup-T1, SUPT-1, SupT-1, Sup T-1, SUP T-1, SUP T1, Sup T1, SupT1, SUPT1, Tsup-1, VB, Stanford University Pediatric T-cell line 1

🤖 AI SummaryBased on 13 publications

Quick Overview

Human T-cell lymphoblastic lymphoma cell line for cancer research.

Detailed Summary

The SUP-T1 cell line is a human T-cell lymphoblastic lymphoma cell line derived from a patient with T-cell lymphoma. It is widely used in research for studying T-cell malignancies, including mechanisms of cell proliferation, apoptosis, and immune evasion. The cell line exhibits characteristics of T-cell lineage, including expression of CD4 and CD8 markers, and has been utilized in studies involving viral interactions, such as HIV and HHV-6B. Its utility in understanding T-cell receptor (TCR) gene rearrangements and chromosomal abnormalities, such as inv(14), has been documented in multiple studies. The cell line is also used to investigate the role of CD4 in viral entry and the molecular mechanisms of T-cell lymphoma progression.

Research Applications

T-cell lymphoma researchViral entry mechanisms (e.g., HIV, HHV-6B)T-cell receptor (TCR) gene rearrangementsChromosomal abnormalities (e.g., inv(14))Apoptosis and cell proliferation studies

Key Characteristics

Expresses CD4 and CD8 markersUsed in studies of T-cell receptor (TCR) gene rearrangementsInvolved in research on chromosomal inversions (inv(14))Utilized for investigating viral interactions with T-cells

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1714
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	8
Age Category	Pediatric
Sex	Male
Race	caucasian
Subtype Features	TAL1 DP-like

Disease Information

Disease	Childhood T lymphoblastic lymphoma
Lineage	Lymphoid
Subtype	T-Lymphoblastic Leukemia/Lymphoma
OncoTree Code	TLL

DepMap Information

Source Type	ATCC
Source ID	ACH-000953_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	EGFR	p.Cys251Tyr (c.752G>A)	Heterozygous	-	from parent cell line SupT1/Blam
MutationSimple	KIT	p.Arg177His (c.530G>A)	Heterozygous	-	from parent cell line SupT1/Blam
MutationSimple	MET	p.Arg191Trp (c.571C>T)	Heterozygous	-	from parent cell line SupT1/Blam
MutationSimple	PIK3CA	p.Glu545Asp (c.1635G>T)	Heterozygous	-	from parent cell line SupT1/Blam
MutationSimple	PIK3CA	p.Glu970Lys (c.2908G>A)	Heterozygous	-	from parent cell line SupT1/Blam
MutationSimple	PTCH1	p.Arg682Cys (c.2044C>T)	Heterozygous	-	from parent cell line SupT1/Blam
MutationSimple	SPRY4	p.Arg25Trp (c.73C>T)	Heterozygous	-	from parent cell line SupT1/Blam
MutationSimple	TP53	p.Arg267Leu (c.800G>T)	Heterozygous	-	from parent cell line SupT1/Blam

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11

D13S317

10,11,12

D16S539

9,10,11,13

D18S51

13,14

D19S433

13,27

D21S11

28,29,32.2,33.2

D2S1338

25,26

D3S1358

16,17,18,19

D5S818

10,11,12

D7S820

D8S1179

13,14

FGA

19,20,21

Penta D

Penta E

13,14,16

TH01

9.3

TPOX

8,9

vWA

16,17,18,19

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

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Publications

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Cytogenetic and immunophenotypic analysis of cell lines established from patients with T cell leukemia/lymphoma.

Smith S.D., Morgan R., Link M.P., McFall P., Hecht F.

Blood 67:650-656(1986).

DOI PubMed

AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen.

Lifson J.D., Reyes G.R., McGrath M.S., Stein B.S., Engleman E.G.

Science 232:1123-1127(1986).

DOI PubMed

The mechanism of chromosome 14 inversion in a human T cell lymphoma.

Baer R., Forster A., Rabbitts T.H.

Cell 50:97-105(1987).

DOI PubMed

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane.

Engleman E.G.

Cell 49:659-668(1987).

DOI PubMed

Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors.

Baer R., Chen K.-C., Smith S.D., Rabbitts T.H.

Cell 43:705-713(1985).

DOI PubMed

Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines.

Smith S.D., Shatsky M., Cohen P.S., Warnke R.A., Link M.P., Glader B.E.

Cancer Res. 44:5657-5660(1984).

PubMed

Common region on chromosome 14 in T-cell leukemia and lymphoma.";

Hecht F., Morgan R., Kaiser-McCaw Hecht B., Smith S.D.

Science 226:1445-1447(1984).

DOI PubMed

Deletions and rearrangement of CDKN2 in lymphoid malignancy.";

Millar J.L., Catovsky D., Dyer M.J.S.

Blood 85:893-901(1995).

DOI PubMed

The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.

Quentmeier H., Drexler H.G.

Leukemia 10:142-149(1996).

PubMed

Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.

Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.

Leuk. Res. 23:19-27(1999).

DOI PubMed

Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4.

Desrosiers R.C.

J. Virol. 75:3903-3915(2001).

DOI PubMed PMC

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Langerak A.W.

Leukemia 21:230-237(2007).

DOI PubMed

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Molecular cloning of a novel PPEF-1 gene variant from a T-cell lymphoblastic lymphoma cell line.

Ho P., Dai K.-S., Chen H.-L.

Recent Pat. DNA Gene Seq. 6:72-77(2012).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

High accuracy mutation detection in leukemia on a selected panel of cancer genes.

Cools J., Aerts S.

PLoS ONE 7:E38463-E38463(2012).

DOI PubMed PMC

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Evaluation of a method to measure HHV-6B infection in vitro based on cell size.

Becerra-Artiles A., Santoro T., Stern L.J.

Virol. J. 15:4.1-4.15(2018).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Elucidating the basis for permissivity of the MT-4 T-cell line to replication of an HIV-1 mutant lacking the gp41 cytoplasmic tail.

van Engelenburg S.B., Freed E.O.

J. Virol. 94:e01334.20.1-e01334.20.27(2020).

DOI PubMed PMC

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Web Resources

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