SW1088Homo sapiens (Human)Cancer cell line

Also known as: SW 1088, SW-1088

🤖 AI SummaryBased on 11 publications

Quick Overview

Human astrocytoma cell line for cancer research.

Detailed Summary

SW1088 is a human astrocytoma cell line derived from a brain tumor. It is widely used in cancer research for studying tumor biology and drug development. The cell line has been characterized in multiple studies, including its genetic and molecular profiles. Research involving SW1088 has contributed to understanding the mechanisms of cancer progression and therapeutic responses. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies related to genomic alterations and drug sensitivity. The cell line is also utilized in investigations of tumor cell behavior and potential therapeutic targets.

Research Applications

Cancer researchDrug developmentGenomic studiesTumor biologyTherapeutic response studies

Key Characteristics

Used in the Cancer Cell Line Encyclopedia (CCLE)Characterized in multiple studiesRelevant for understanding cancer progression
Generated on 6/17/2025

Basic Information

Database IDCVCL_1715
SpeciesHomo sapiens (Human)

Donor Information

Age72
Age CategoryAdult
SexMale
Racecaucasian

Disease Information

DiseaseAstrocytoma
LineageCNS/Brain
SubtypeAstrocytoma
OncoTree CodeASTR

DepMap Information

Source TypeATCC
Source IDACH-000437_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Arg273Cys (c.817C>T)Homozygous-PubMed=35933914
MutationSimpleNRASp.Gln61Lys (c.181C>A)UnspecifiedAcquired during resistance selection processPubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
10,12
D13S317
12
D16S539
12,13
D18S51
14,18
D19S433
15
D21S11
29,33.2
D2S1338
17,23
D3S1358
13,16
D5S818
11
D7S820
9
D8S1179
13,15
FGA
19,22
Penta D
9,12
Penta E
5,12
TH01
7,9.3
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.

Fine H.A.

Cancer Cell 9:391-403(2006).

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.

Wolf E., Gabius H.-J.

J. Cancer Res. Clin. Oncol. 127:375-386(2001).

Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.

Rousset M., Zweibaum A., Fogh J.

Cancer Res. 41:1165-1170(1981).

Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.

Wright W.C., Daniels W.P., Fogh J.

J. Natl. Cancer Inst. 66:239-247(1981).

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

Fogh J., Fogh J.M., Orfeo T.

J. Natl. Cancer Inst. 59:221-226(1977).

Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

Herlyn M., Steplewski Z., Herlyn D., Koprowski H.

Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979).

Brain tumors.";

Ali-Osman F.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).