SW1271Homo sapiens (Human)Cancer cell line

Also known as: SW 1271, SW-1271

🤖 AI SummaryBased on 5 publications

Quick Overview

SW1271 is a human epithelial cell line used in cancer research, particularly in studies related to small-cell lung carcinoma (S...

Detailed Summary

SW1271 is a human epithelial cell line derived from small-cell lung carcinoma (SCLC). It is widely used in cancer research, particularly in studies focused on the genetic and molecular mechanisms of SCLC. This cell line has been utilized in investigations involving the identification of genomic markers associated with drug sensitivity, such as the amplification of the Bcl-2 gene on chromosome 18q21.3, which correlates with sensitivity to Bcl-2 inhibitors like ABT-737. Research on SW1271 has contributed to understanding the role of Bcl-2 and NOXA in apoptosis regulation and their implications for cancer therapy. Additionally, SW1271 has been part of studies examining the clinical relevance of 18q21-23 copy number gains in SCLC, highlighting its importance in predicting response to Bcl-2 family inhibitors. The cell line's utility in drug sensitivity profiling and its role in elucidating the genetic basis of SCLC make it a valuable resource for cancer research.

Research Applications

Genomic marker identification for drug sensitivityApoptosis regulation studiesBcl-2 and NOXA gene amplification analysisSmall-cell lung carcinoma (SCLC) researchDrug sensitivity profiling

Key Characteristics

Amplification of Bcl-2 gene on 18q21.3Sensitivity to Bcl-2 inhibitors like ABT-737Expression of Bcl-2 and NOXA genes18q21-23 copy number gainsUsed in studies of SCLC tumor biology

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1716
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	69
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	SMARCA4-deficient undifferentiated tumor

DepMap Information

Source Type	ATCC
Source ID	ACH-000890_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys277Phe (c.830G>T)	Unspecified	-	Unknown
MutationSimple	SMARCA4	p.Asn774Lys (c.2322C>A)	Homozygous	-	Unknown
MutationSimple	NRAS	p.Gln61Arg (c.182A>G)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D10S1248

13,16

D12S391

18,20

D13S317

D16S539

11,12

D18S51

D19S433

D1S1656

D21S11

29,31.2

D22S1045

D2S1338

D2S441

D3S1358

D5S818

D7S820

9,12

D8S1179

13,16

FGA

Penta D

10,12

Penta E

5,12

TH01

7,8

TPOX

vWA

17,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Molecular and pathologic characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies.

Burr M.L., Sutherland K.D.

Clin. Cancer Res. 30:1846-1858(2024).

DOI PubMed PMC

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.

Sauter G., Lesniewski R., Semizarov D.

Mol. Cancer Res. 5:331-339(2007).

DOI PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

Gerwin B.I., Harris C.C.

Cancer Res. 51:4090-4096(1991).

PubMed