Back to Cell Types

SW1463Homo sapiens (Human)Cancer cell line

Also known as: SW 1463, SW-1463

🤖 AI SummaryBased on 14 publications

Quick Overview

SW1463 is a colorectal cancer cell line used in cancer research.

Detailed Summary

SW1463 is a colorectal cancer cell line derived from a human tumor. It is widely used in research to study the molecular mechanisms of cancer, particularly in the context of colorectal cancer. This cell line has been characterized in multiple studies for its genetic and molecular profiles, including mutations and gene expression patterns. Research on SW1463 has contributed to understanding the genetic diversity and heterogeneity of colorectal cancers, and it is utilized in studies related to drug sensitivity and resistance. The cell line is part of several large-scale cancer research initiatives, including the Cancer Cell Line Encyclopedia (CCLE) and other comprehensive genomic studies.

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1718
Species	Homo sapiens (Human)
Tissue Source	Rectum[UBERON:UBERON_0001052]

Donor Information

Age	66
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Rectal adenocarcinoma
Lineage	Bowel
Subtype	Rectal Adenocarcinoma
OncoTree Code	READ

DepMap Information

Source Type	ATCC
Source ID	ACH-000470_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Gln (c.743G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=20575032
MutationSimple	KRAS	p.Gly12Cys (c.34G>T)	Unspecified	-	PubMed=21173094
MutationSimple	FBXW7	p.Arg479Gln (c.1436G>A)	Heterozygous	-	Unknown, Unknown
MutationSimple	APC	p.Val452Serfs*7 (c.1348_1349GT[3]) (c.1354_1355delGT)	Homozygous	-	Unknown, Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11,12

D12S391

17

D13S317

12,13

D16S539

11

D18S51

18

D19S433

14,15

D21S11

30,31.2

D2S1338

17,18

D3S1358

16,17

D5S818

13,14

D6S1043

12,18

D7S820

9

D8S1179

11,15

FGA

23,28

Penta D

9,12

Penta E

17

TH01

6,7

TPOX

8,11

vWA

16

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

Genomic determinants of protein abundance variation in colorectal cancer cells.

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.

Cell Rep. 20:2201-2214(2017).

Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.

Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.

Mol. Cancer 16:116.1-116.16(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression.

Tollenaar R.A.E.M., Rombouts Y., Wuhrer M.

Mol. Cell. Proteomics 15:124-140(2016).

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Mariadason J.M., Sieber O.M.

Cancer Res. 74:3238-3247(2014).

Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.

Grade M., Gaedcke J.

Radiother. Oncol. 108:451-457(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

Karyotype consistency in human colorectal carcinoma cell lines established in vitro.

Chen T.-R., Hay R.J., Macy M.L.

Cancer Genet. Cytogenet. 6:93-117(1982).

Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.

Kerbel R.S., Pross H.F., Leibovitz A.

Int. J. Cancer 20:673-679(1977).