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SW1573Homo sapiens (Human)Cancer cell line

Also known as: SW 1573, SW-1573, SW1753 (Occasionally.), SW-1753 (Occasionally.)

🤖 AI SummaryBased on 13 publications

Quick Overview

Human cancer cell line for research on cancer biology and drug development.

Detailed Summary

SW1573 is a human cancer cell line derived from a tumor, widely used in cancer research. It is utilized in studies related to cancer biology, drug sensitivity, and molecular mechanisms. The cell line is part of various research initiatives, including genomic and proteomic analyses, and is employed in investigations of cancer cell line diversity and therapeutic responses. Its applications span across multiple cancer types, contributing to the understanding of tumor genetics and treatment strategies.

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1720
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	44
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Minimally invasive lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000677_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	SMARCB1	c.362+1G>C	Heterozygous	Splice donor mutation	from parent cell line SW1573/S1
MutationSimple	PIK3CA	p.Lys111Glu (c.331A>G)	Heterozygous	-	from parent cell line SW1573/S1
MutationSimple	KRAS	p.Gly12Cys (c.34G>T)	Unspecified	-	PubMed=21173094
MutationSimple	CTNNB1	p.Ser33Phe (c.98C>T)	Heterozygous	-	PubMed=31953491
Gene deletion	SMAD4	-	Homozygous	-	from parent cell line BxPC-3
Gene deletion	CDKN2A	-	Homozygous	Possible	PubMed=26870271

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,12

D13S317

11

D16S539

12,14

D18S51

16

D19S433

13

D21S11

29

D2S1338

19,20

D3S1358

14,18

D5S818

12,13

D7S820

9,11

D8S1179

11

FGA

21

Penta D

9

Penta E

5,13

TH01

6,9.3

TPOX

8,11

vWA

20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Proteome analysis of non-small cell lung cancer cell line secretomes and patient sputum reveals biofluid biomarker candidates for cisplatin response prediction.

Jimenez C.R.

J. Proteomics 196:106-119(2019).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.

Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.

Br. J. Cancer 109:1599-1608(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.

Peters G.J.

Biochem. Pharmacol. 53:1855-1866(1997).

Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.

Wright W.C., Daniels W.P., Fogh J.

J. Natl. Cancer Inst. 66:239-247(1981).

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells.

Schoonen W.G.E.J., van Rijn J., Pinedo H.M., Joenje H.

Cancer Res. 49:2988-2993(1989).

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line.

Joenje H.

Cancer Res. 50:5392-5398(1990).

Cytogenetic alterations associated with P-glycoprotein- and non-P-glycoprotein-mediated multidrug resistance in SW-1573 human lung tumor cell lines.

Nieuwint A.W.M., Baas F., Wiegant J., Joenje H.

Cancer Res. 52:4361-4371(1992).

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