SW1783Homo sapiens (Human)Cancer cell line

Also known as: SW 1783, SW-1783

🤖 AI SummaryBased on 8 publications

Quick Overview

Human astrocytoma cell line for cancer research and drug development.

Detailed Summary

SW1783 is a human astrocytoma cell line derived from a brain tumor. It is widely used in cancer research for studying tumor biology, drug sensitivity, and genetic characteristics. This cell line has been utilized in various studies to understand the molecular mechanisms of cancer and to develop targeted therapies. SW1783 is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its genomic and transcriptomic profiles, contributing to the understanding of cancer genetics and therapeutic responses. Its applications include research on cell proliferation, drug screening, and molecular profiling.

Research Applications

Cancer researchDrug developmentGenomic profilingMolecular biologyCell proliferation studies

Key Characteristics

Human astrocytoma cell linePart of CCLEUsed in drug sensitivity studiesGenomic and transcriptomic analysis

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1722
Species	Homo sapiens (Human)

Donor Information

Age	68
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Anaplastic astrocytoma
Lineage	CNS/Brain
Subtype	Anaplastic Astrocytoma
OncoTree Code	AASTR

DepMap Information

Source Type	ATCC
Source ID	ACH-000883_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273His (c.818G>A)	Homozygous	-	Unknown, PubMed=16264262
MutationSimple	TP53	p.Arg273Cys (c.817C>T)	Homozygous	-	PubMed=35933914
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	PTEN	p.Arg233Ter (c.697C>T)	Heterozygous	-	PubMed=28683746, PubMed=24042735

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,13

D13S317

9,11

D16S539

D18S51

10,12,13

D19S433

D21S11

29,31

D2S1338

21,25

D3S1358

14,15

D5S818

D7S820

9,13

D8S1179

10,11

FGA

Penta D

9,10

Penta E

7,16

TH01

6,8

TPOX

8,11

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.

Wolf E., Gabius H.-J.

J. Cancer Res. Clin. Oncol. 127:375-386(2001).

DOI PubMed

Polymorphic enzyme analysis of cultured human tumor cell lines.";

Dracopoli N.C., Fogh J.

J. Natl. Cancer Inst. 70:469-476(1983).

PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

Herlyn M., Steplewski Z., Herlyn D., Koprowski H.

Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979).

DOI PubMed PMC

Brain tumors.";

Ali-Osman F.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).

DOI