SW756Homo sapiens (Human)Cancer cell line

Also known as: SW 756, SW-756

🤖 AI SummaryBased on 10 publications

Quick Overview

Human cervical carcinoma cell line with HPV18 integration

Detailed Summary

SW756 is a human cervical carcinoma cell line derived from a primary cervical carcinoma. It is known for its HPV18 integration, which has been mapped to chromosome 12. The cell line exhibits characteristics of squamous cell carcinoma and is used in research related to cervical cancer biology and HPV-associated malignancies. SW756 has been utilized in studies investigating the molecular mechanisms of HPV integration, its impact on cellular transformation, and the role of viral oncogenes in tumorigenesis. The cell line is also notable for its use in studies examining the relationship between HPV infection and cancer progression, as well as in the development of targeted therapies against HPV-driven cancers.

Research Applications

HPV integration studiesCervical cancer biologyViral oncogene functionTumorigenesis mechanismsTargeted therapy development

Key Characteristics

HPV18 integrationSquamous cell carcinoma originUsed in HPV-related cancer research

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1727
Species	Homo sapiens (Human)
Tissue Source	Uterus, cervix[UBERON:UBERON_0000002]

Donor Information

Age	46
Age Category	Adult
Sex	Female

Disease Information

Disease	Squamous cell carcinoma of the cervix uteri
Lineage	Cervix
Subtype	Cervical Squamous Cell Carcinoma
OncoTree Code	CESC

DepMap Information

Source Type	ATCC
Source ID	ACH-001402_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KRAS	p.Gly12Cys (c.34G>T)	Unspecified	-	PubMed=21173094

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

D16S539

12,13

D18S51

14,17

D21S11

D3S1358

15,17

D5S818

11,12

D7S820

10,12

D8S1179

11,13

FGA

20,22

Penta D

9,12

Penta E

11,12

TH01

9.3

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Establishment, authenticity, and characterization of cervical cancer cell lines.

Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.

Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.

Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.

Oncotarget 8:86369-86383(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Individual karyotypes at the origins of cervical carcinomas.";

Duesberg P.H.

Mol. Cytogenet. 6:44.1-44.23(2013).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Smad4 deficiency in cervical carcinoma cells.";

Schwarte-Waldhoff I.

Oncogene 24:810-819(2005).

DOI PubMed

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

DOI PubMed

Characterization of a cell line (SW756) derived from a human squamous carcinoma of the uterine cervix.

Gallager H.S., Giovanella B.C.

In Vitro 18:719-726(1982).

DOI PubMed

Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.

Wright W.C., Daniels W.P., Fogh J.

J. Natl. Cancer Inst. 66:239-247(1981).

DOI PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.

Durst M., Croce C.M., Gissmann L., Schwarz E., Huebner K.

Proc. Natl. Acad. Sci. U.S.A. 84:1070-1074(1987).

DOI PubMed PMC

Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.

Kerbel R.S., Pross H.F., Leibovitz A.

Int. J. Cancer 20:673-679(1977).

DOI PubMed

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

DOI PubMed