SW954Homo sapiens (Human)Cancer cell line
Also known as: SW 954, SW-954
🤖 AI SummaryBased on 5 publications
Quick Overview
Human cancer cell line with known genetic alterations.
Detailed Summary
SW954 is a human cancer cell line derived from a vulvar carcinoma. It is used in cancer research to study genetic alterations and their implications in tumor development. The cell line has been characterized for specific mutations and deletions that may contribute to its malignant properties. Research on SW954 focuses on understanding the molecular mechanisms underlying cancer progression and identifying potential therapeutic targets.
Research Applications
Genetic alteration studiesCancer progression mechanismsTherapeutic target identification
Key Characteristics
Known mutations in polarity complex genesHomozygous deletions in specific regionsUsed for in vitro studies of cancer biology
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1732 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Vulva[UBERON:UBERON_0000997] |
Donor Information
| Age | 86 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Vulvar squamous cell carcinoma |
|---|---|
| Lineage | Vulva/Vagina |
| Subtype | Squamous Cell Carcinoma of the Vulva/Vagina |
| OncoTree Code | VSC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001400_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg158His (c.473G>A) | Homozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
9,11
D16S539
11
D18S51
20
D19S433
14,15
D21S11
30,31
D2S1338
20,24
D3S1358
16
D5S818
11,12
D7S820
11,13
D8S1179
10,13
FGA
23
Penta D
12,13
Penta E
9,14
TH01
8,9.3
TPOX
8
vWA
14,15
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).