SW982Homo sapiens (Human)Cancer cell line

Also known as: SW 982, SW-982

🤖 AI SummaryBased on 9 publications

Quick Overview

SW982 is a human cancer cell line used in research for sarcomas and other cancers.

Detailed Summary

SW982 is a human cancer cell line derived from a synovial sarcoma. It is commonly used in cancer research, particularly in studies involving sarcomas and other malignancies. The cell line has been characterized in various studies for its genetic and molecular properties, including its response to different therapeutic agents. Research on SW982 has contributed to understanding the mechanisms of cancer progression and drug sensitivity in sarcomas. The cell line is part of several large-scale studies that aim to identify potential targets for cancer therapy and to understand the genetic basis of cancer.

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1734
Species	Homo sapiens (Human)
Tissue Source	Synovium[UBERON:UBERON_0007616]

Donor Information

Age	25
Age Category	Adult
Sex	Female

Disease Information

Disease	Synovial sarcoma
Lineage	Soft Tissue
Subtype	Synovial Sarcoma
OncoTree Code	SYNS

DepMap Information

Source Type	Academic lab
Source ID	ACH-001274_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590
Gene deletion	MPDZ	-	Homozygous	-	PubMed=20215515

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

8,12,13

D16S539

11,12

D18S51

16,18

D19S433

12,15

D21S11

28,30

D2S1338

19,20

D3S1358

D5S818

11,13

D7S820

9,11

D8S1179

11,14

FGA

21,24

Penta D

10,13

Penta E

13,15

TH01

9.3

TPOX

9,11

vWA

19,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.

Harris E., Monks A., Morris J.

Mol. Cancer Ther. 14:2452-2462(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Phenotypic characterization of a human synovial sarcoma cell line, SW982, and its response to dexamethasone.

Yamazaki T., Yokoyama T., Akatsu H., Tukiyama T., Tokiwa T.

In Vitro Cell. Dev. Biol. Anim. 39:337-339(2003).

DOI PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

DOI PubMed

Development, availability and characterization of ATCC human and animal cell lines.

Hay R.J.

(In book chapter) Animal cell culture and production of biologicals; Sasaki R., Ikura K. (eds.); pp.27-39; Springer; Dordrecht; Netherlands (1991).

DOI

Web Resources

tcpaportal.org