SU-DHL-5Homo sapiens (Human)Cancer cell line

Also known as: DHL5, DHL-5, Stanford University-Diffuse Histiocytic Lymphoma-5, SuDHL 5, SU-DH-L5, SUDHL-5, SUDHL5, Su-DHL-5

🤖 AI SummaryBased on 13 publications

Quick Overview

SU-DHL-5 is a human cell line derived from diffuse large B-cell lymphoma, used in cancer research for studying genetic and mole...

Detailed Summary

SU-DHL-5 is a human cell line established from a diffuse large B-cell lymphoma (DLBCL) and is widely used in cancer research. It is known for its utility in studying genetic alterations, such as deletions in the MTS1/p16 and MTS2/p15 genes, which are associated with lymphoid malignancies. This cell line has been utilized in studies examining the role of these genes in tumor suppression and their implications in lymphoma progression. Additionally, SU-DHL-5 has been part of research on the molecular mechanisms of DLBCL, including the identification of specific genetic signatures and their correlation with clinical outcomes. The cell line is also used in investigations related to the immune response and the development of targeted therapies. Its characteristics make it a valuable model for understanding the complexities of B-cell lymphomas and for testing potential therapeutic strategies.

Research Applications

Genetic and molecular mechanism studiesTumor suppressor gene analysisLymphoma progression researchImmune response investigationsTargeted therapy development

Key Characteristics

Deletion of MTS1/p16 and MTS2/p15 genesUsed in studies of DLBCL molecular signaturesRelevant for understanding lymphoma pathogenesis

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1735
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	17
Age Category	Pediatric
Sex	Female

Disease Information

Disease	Diffuse large B-cell lymphoma
Lineage	Lymphoid
Subtype	Diffuse Large B-Cell Lymphoma, NOS
OncoTree Code	DLBCLNOS

DepMap Information

Source Type	DSMZ
Source ID	ACH-000660_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,13

D13S317

D16S539

11,13

D18S51

13,15

D19S433

13,14

D21S11

28,30

D2S1338

17,18

D3S1358

15,16

D5S818

12,15

D7S820

D8S1179

13,15

FGA

22,23

Penta D

11,12

Penta E

5,19

TH01

6,9

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation.

Zaborski M., Drexler H.G.

Oncotarget 7:63456-63465(2016).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.

Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.

Leuk. Lymphoma 57:1015-1020(2016).

DOI PubMed

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

Kutok J.L., Shipp M.A.

Blood 116:3268-3277(2010).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.

Robetorye R.S., Aguiar R.C.T.

Blood 113:6681-6690(2009).

DOI PubMed PMC

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.

Grever M.R., Byrd J.C., Botstein D., Brown P.O., Staudt L.M.

Nature 403:503-511(2000).

DOI PubMed

PTEN gene alterations in lymphoid neoplasms.";

Sakai A., Thieblemont C., Wellmann A., Jaffe E.S., Raffeld M.

Blood 92:3410-3415(1998).

DOI PubMed

Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.

Uppenkamp M.J., Nowrousian M.R., Seeber S., Opalka B.

Br. J. Haematol. 91:350-354(1995).

DOI PubMed

Histiocytic lymphoma cell lines: immunologic and cytogenetic studies.

Hecht F.

Cancer Genet. Cytogenet. 14:205-218(1985).

DOI PubMed

Feeder layer and nutritional requirements for the establishment and cloning of human malignant lymphoma cell lines.

Epstein A.L., Kaplan H.S.

Cancer Res. 39:1748-1759(1979).

PubMed

Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.

Epstein A.L., Levy R., Kim H., Henle W., Henle G.S., Kaplan H.S.

Cancer 42:2379-2391(1978).

DOI PubMed

Biology of the human malignant lymphomas. III. Intracranial heterotransplantation in the nude, athymic mouse.

Epstein A.L., Herman M.M., Kim H., Dorfman R.F., Kaplan H.S.

Cancer 37:2158-2176(1976).

DOI PubMed

Biology and virology of the human malignant lymphomas: 1st Milford D. Schulz Lecture.

Kaplan H.S., Goodenow R.S., Gartner S., Bieber M.M.

Cancer 43:1-24(1979).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

tcpaportal.org