TE-1Homo sapiens (Human)Cancer cell line

Also known as: TE1

🤖 AI SummaryBased on 13 publications

Quick Overview

Human esophageal squamous cell carcinoma cell line for cancer research.

Detailed Summary

TE-1 is a human esophageal squamous cell carcinoma cell line established from a primary tumor. It is widely used in research for studying the molecular mechanisms of esophageal cancer. The cell line exhibits characteristics of squamous cell carcinoma, including specific chromosomal abnormalities and genetic mutations. TE-1 has been utilized in studies related to tumor suppressor genes, oncogenes, and drug sensitivity. Research on TE-1 has contributed to understanding the genetic and epigenetic changes associated with esophageal carcinogenesis.

Research Applications

cancer researchmolecular mechanisms of esophageal cancertumor suppressor genesoncogenesdrug sensitivity

Key Characteristics

chromosomal abnormalitiesgenetic mutationsepigenetic changes

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1759
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	58
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	JCRB
Source ID	ACH-000647_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Val272Met (c.814G>A)	Unspecified	-	from parent cell line TE-1

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

D16S539

D18S51

D19S433

14,15.2

D21S11

D2S1338

19,20

D3S1358

D5S818

D7S820

D8S1179

11,13

FGA

TH01

TPOX

8,11

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Anlotinib inhibits tumor angiogenesis and promotes the anticancer effect of radiotherapy on esophageal cancer through inhibiting EphA2.

Huang J.

J. Oncol. 2022:5632744.1-5632744.11(2022).

DOI PubMed PMC

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

RNA-Seq analysis of human cell lines established from normal and neoplastic esophageal squamous epithelium.

Akagi I., Ishibashi O.

Genom. Data 12:4-6(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.

Sasaki K., Hanazawa T., Okamoto Y., Hata A.

Genes Chromosomes Cancer 48:132-142(2009).

DOI PubMed

Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7.

Lowe A.W., Beverloo H.B., van Dekken H., Tilanus H.W., Dinjens W.N.M.

Cancer Res. 67:7996-8001(2007).

DOI PubMed

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

Inactivation of the p53 protein in cell lines derived from human esophageal cancers.

Hainaut P.

Int. J. Cancer 71:79-87(1997).

DOI PubMed

Molecular and cellular features of esophageal cancer cells.";

Nishihira T., Hashimoto Y., Katayama M., Mori S., Kuroki T.

J. Cancer Res. Clin. Oncol. 119:441-449(1993).

DOI PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.

Am. J. Pathol. 119:361-366(1985).

PubMed PMC

Human esophageal carcinoma cells have fewer, but higher affinity epidermal growth factor receptors.

Banks-Schlegel S.P., Quintero J.

J. Biol. Chem. 261:4359-4362(1986).

DOI PubMed

Cytogenetic studies of esophageal carcinoma cell lines.";

Whang-Peng J., Banks-Schlegel S.P., Lee E.C.

Cancer Genet. Cytogenet. 45:101-120(1990).

DOI PubMed

Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.

Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.

Jpn. J. Cancer Res. 82:1428-1435(1991).

DOI PubMed PMC

Characteristics of two cell lines (TE-1 and TE-2) derived from human squamous cell carcinoma of the esophagus.

Kitamura M., Hirayama K., Akaishi T., Sasaki T.

Gann 70:575-584(1979).

DOI PubMed

Comprehensive analysis of microRNA and mRNA expression in normal and tumorous human esophageal squamous cell lines using microarray datasets.

Makino H., Yoshida H., Miyashita M., Uchida E.

Dataset Papers Sci. 2013:376541.1-376541.3(2013).

DOI