Back to Cell Types

TE-11Homo sapiens (Human)Cancer cell line

Also known as: Te11, TE11

🤖 AI SummaryBased on 10 publications

Quick Overview

Human esophageal squamous cell carcinoma cell line

Detailed Summary

TE-11 is a human esophageal squamous cell carcinoma cell line derived from a primary tumor. It is widely used in cancer research to study the molecular mechanisms of esophageal carcinogenesis. The cell line has been characterized for its genetic and epigenetic alterations, including frequent homozygous deletions of the LRP1B gene and methylation of its CpG island. TE-11 is also utilized in studies investigating the role of p53 mutations and their impact on cancer progression. Additionally, it has been employed in research on the effects of DNA methylation on gene expression and tumor suppression. The cell line's utility in drug sensitivity profiling and its role in understanding cancer cell biology make it a valuable resource for cancer research.

Research Applications

Molecular mechanisms of esophageal carcinogenesisGenetic and epigenetic alterationsp53 mutation analysisDNA methylation studiesDrug sensitivity profiling

Key Characteristics

Homozygous deletions of LRP1BCpG island methylationp53 mutationsEpigenetic regulation of gene expression

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1761
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	58
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000488_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg110Leu (c.329G>T)	Unspecified	-	PubMed=10741724, PubMed=7732013

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

9,12

D13S317

10

D16S539

10,11

D5S818

8,14

D7S820

11,12

TH01

9

TPOX

11

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7.

Lowe A.W., Beverloo H.B., van Dekken H., Tilanus H.W., Dinjens W.N.M.

Cancer Res. 67:7996-8001(2007).

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

Expression of G1 cell cycle markers and the effect of adenovirus-mediated overexpression of p21Waf-1 in squamous cell carcinoma of the esophagus.

Morimatsu M.

Int. J. Oncol. 18:157-163(2001).

A wild-type sequence p53 peptide presented by HLA-A24 induces cytotoxic T lymphocytes that recognize squamous cell carcinomas of the head and neck.

Song Y.-S., Appella E., Whiteside T.L., DeLeo A.B.

Clin. Cancer Res. 6:979-986(2000).

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.

Itoh K.

Cell. Immunol. 177:176-181(1997).

Inactivation of the p53 protein in cell lines derived from human esophageal cancers.

Hainaut P.

Int. J. Cancer 71:79-87(1997).

HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.

Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.

Cell. Immunol. 175:101-110(1997).

Molecular and cellular features of esophageal cancer cells.";

Nishihira T., Hashimoto Y., Katayama M., Mori S., Kuroki T.

J. Cancer Res. Clin. Oncol. 119:441-449(1993).

A simple p53 functional assay for screening cell lines, blood, and tumors.

Tada M., Van Meir E.G., Estreicher A., Iggo R.D.

Proc. Natl. Acad. Sci. U.S.A. 92:3963-3967(1995).