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TE-5Homo sapiens (Human)Cancer cell line

Also known as: TE5

🤖 AI SummaryBased on 9 publications

Quick Overview

Human esophageal squamous cell carcinoma cell line

Detailed Summary

TE-5 is a human esophageal squamous cell carcinoma cell line established from a primary tumor. It is part of the TE-series cell lines, which are widely used in cancer research. The cell line exhibits characteristics of squamous cell carcinoma, including specific chromosomal abnormalities and gene expression profiles. Research on TE-5 has contributed to understanding the molecular mechanisms of esophageal cancer, including the role of tumor suppressor genes and oncogenes. The cell line is utilized in studies related to cancer biology, drug development, and genetic analysis.

Research Applications

cancer biologydrug developmentgenetic analysis

Key Characteristics

chromosomal abnormalitiesgene expression profilestumor suppressor gene inactivation

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1764
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	73
Age Category	Adult
Sex	Female

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000408_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Val272Leu (c.814G>T)	Unspecified	-	PubMed=7732013

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

13

D13S317

10

D16S539

9,10

D5S818

9

D7S820

11

TH01

7

TPOX

11

vWA

16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

RNA-Seq analysis of human cell lines established from normal and neoplastic esophageal squamous epithelium.

Akagi I., Ishibashi O.

Genom. Data 12:4-6(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7.

Lowe A.W., Beverloo H.B., van Dekken H., Tilanus H.W., Dinjens W.N.M.

Cancer Res. 67:7996-8001(2007).

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

Molecular and cellular features of esophageal cancer cells.";

Nishihira T., Hashimoto Y., Katayama M., Mori S., Kuroki T.

J. Cancer Res. Clin. Oncol. 119:441-449(1993).

A simple p53 functional assay for screening cell lines, blood, and tumors.

Tada M., Van Meir E.G., Estreicher A., Iggo R.D.

Proc. Natl. Acad. Sci. U.S.A. 92:3963-3967(1995).

Comprehensive analysis of microRNA and mRNA expression in normal and tumorous human esophageal squamous cell lines using microarray datasets.

Makino H., Yoshida H., Miyashita M., Uchida E.

Dataset Papers Sci. 2013:376541.1-376541.3(2013).