TE-6Homo sapiens (Human)Cancer cell line

Also known as: TE6

🤖 AI SummaryBased on 7 publications

Quick Overview

Human esophageal squamous cell carcinoma cell line with known LRP1B inactivation mechanisms.

Detailed Summary

The TE-6 cell line is a human esophageal squamous cell carcinoma cell line derived from a primary tumor. It exhibits frequent homozygous deletions of the LRP1B gene, which is associated with tumor suppressor function. Research has shown that LRP1B inactivation occurs through both homozygous deletions and epigenetic silencing via DNA methylation. The cell line is used to study mechanisms of esophageal carcinogenesis and has been characterized in genomic and epigenetic studies. It is also part of large-scale cancer cell line databases like the Cancer Cell Line Encyclopedia (CCLE) and the Catalogue of Somatic Mutations in Cancer (COSMIC).

Research Applications

Genomic and epigenetic studies of LRP1B inactivationMechanisms of esophageal carcinogenesisCancer cell line database characterization (CCLE, COSMIC)

Key Characteristics

Frequent homozygous deletions of LRP1BEpigenetic silencing of LRP1B via DNA methylationPart of large cancer cell line repositories

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1765
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	71
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000605_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

D16S539

9,10

D5S818

10,13

D7S820

TH01

6,7

TPOX

vWA

17,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7.

Lowe A.W., Beverloo H.B., van Dekken H., Tilanus H.W., Dinjens W.N.M.

Cancer Res. 67:7996-8001(2007).

DOI PubMed

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

Inactivation of the p53 protein in cell lines derived from human esophageal cancers.

Hainaut P.

Int. J. Cancer 71:79-87(1997).

DOI PubMed

Molecular and cellular features of esophageal cancer cells.";

Nishihira T., Hashimoto Y., Katayama M., Mori S., Kuroki T.

J. Cancer Res. Clin. Oncol. 119:441-449(1993).

DOI PubMed