TE-8Homo sapiens (Human)Cancer cell line

Also known as: TE8

🤖 AI SummaryBased on 13 publications

Quick Overview

Human esophageal squamous cell carcinoma cell line for cancer research.

Detailed Summary

The TE-8 cell line is a human esophageal squamous cell carcinoma cell line derived from a primary tumor. It is widely used in cancer research to study molecular mechanisms, genetic alterations, and therapeutic responses. TE-8 has been utilized in studies focusing on gene expression, chromosomal abnormalities, and the role of specific genes like LRP1B and FAT in cancer progression. Research involving TE-8 has contributed to understanding the genetic basis of esophageal squamous cell carcinoma and has been instrumental in identifying potential therapeutic targets. The cell line is also used to evaluate the efficacy of drugs and treatments in preclinical models.

Research Applications

Molecular mechanisms of cancer progressionGenetic and epigenetic alterationsDrug efficacy testingGene expression studies

Key Characteristics

Derived from primary esophageal tumorUsed in studies of LRP1B and FAT gene alterationsRelevant for understanding esophageal squamous cell carcinoma

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1766
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	63
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000452_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Met237Ile (c.711G>T)	Unspecified	-	from parent cell line T98G
MutationSimple	TP53	p.Tyr220Cys (c.659A>G)	Unspecified	-	PubMed=21173094

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

D16S539

D5S818

11,12

D7S820

TH01

6,7

TPOX

8,9

vWA

14,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

RNA-Seq analysis of human cell lines established from normal and neoplastic esophageal squamous epithelium.

Akagi I., Ishibashi O.

Genom. Data 12:4-6(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways.

Kusukawa J., Kage M., Shirouzu K., Yamana H.

Mol. Cancer Ther. 9:1842-1851(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7.

Lowe A.W., Beverloo H.B., van Dekken H., Tilanus H.W., Dinjens W.N.M.

Cancer Res. 67:7996-8001(2007).

DOI PubMed

Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.

Hamakawa H.

Oncogene 26:5300-5308(2007).

DOI PubMed

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

DOI PubMed

Expression of G1 cell cycle markers and the effect of adenovirus-mediated overexpression of p21Waf-1 in squamous cell carcinoma of the esophagus.

Morimatsu M.

Int. J. Oncol. 18:157-163(2001).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.

Itoh K.

Cell. Immunol. 177:176-181(1997).

DOI PubMed

HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.

Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.

Cell. Immunol. 175:101-110(1997).

DOI PubMed

Molecular and cellular features of esophageal cancer cells.";

Nishihira T., Hashimoto Y., Katayama M., Mori S., Kuroki T.

J. Cancer Res. Clin. Oncol. 119:441-449(1993).

DOI PubMed

Comprehensive analysis of microRNA and mRNA expression in normal and tumorous human esophageal squamous cell lines using microarray datasets.

Makino H., Yoshida H., Miyashita M., Uchida E.

Dataset Papers Sci. 2013:376541.1-376541.3(2013).

DOI