TGBC1TKBHomo sapiens (Human)Cancer cell line

Also known as: TGBC1, TGBC-1, TGBC1-TKB, TGBC-1TKB, TGBC-1-TKB

🤖 AI SummaryBased on 6 publications

Quick Overview

Human gallbladder cancer cell line for research on tumor biology and drug resistance.

Detailed Summary

TGBC1TKB is a human gallbladder cancer cell line derived from a metastatic lymph node of a poorly differentiated adenocarcinoma. It is used in studies focusing on tumor invasion, drug resistance mechanisms, and genetic alterations associated with cancer progression. Research has shown that TGBC1TKB exhibits specific mutations in genes like TP53 and p53R2, which may contribute to its resistance to therapies such as gemcitabine. This cell line is valuable for investigating the molecular pathways involved in gallbladder cancer development and for testing potential therapeutic strategies.

Research Applications

Tumor invasion and metastasis studiesDrug resistance mechanismsGenetic and molecular profilingCancer therapy development

Key Characteristics

Poorly differentiated adenocarcinoma originMutations in TP53 and p53R2Resistance to gemcitabineIn vitro models for cancer research

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1769
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age Category	Unknown
Sex	Female

Disease Information

Disease	Carcinoma of gallbladder and extrahepatic biliary tract
Lineage	Biliary Tract
Subtype	Gallbladder Cancer
OncoTree Code	GBC

DepMap Information

Source Type	Academic lab
Source ID	ACH-001861_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys176fs*6 (c.525_526insGCGC)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

9,11

D18S51

14,18

D3S1358

D5S818

D7S820

9,13

D8S1179

14,16

FGA

Penta D

Penta E

TH01

TPOX

vWA

14,17

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.

Vazquez F., Getz G., Bardeesy N.M.

bioRxiv 2024:07.04.601970-07.04.601970(2024).

DOI PubMed PMC

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.

Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.

Cancers (Basel) 12:2510.1-2510.14(2020).

DOI PubMed PMC

Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.

Parra Z., Romero D., Kato S., Leal P., Lagos M., Roa J.C.

Biol. Res. 53:13.1-13.17(2020).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Radiosensitivity of human biliary tract cancer cell lines in vitro.";

Moon Y., Dahlberg W.K., Yu Y.-J., Ohno T., Todoroki T., Little J.B.

Int. J. Oncol. 10:545-551(1997).

DOI PubMed

Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma.

Tsuchiya T., Gotoh M.

J. Hepatobiliary Pancreat. Sci. 18:700-711(2011).

DOI PubMed

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

The invasion potentials of human biliary tract carcinoma cell lines: correlation between invasiveness and morphologic characteristics.

Fukao K., Ohno T., Watanabe T.

Int. J. Oncol. 13:1269-1274(1998).

DOI PubMed