VA-ES-BJHomo sapiens (Human)Cancer cell line

Also known as: Valhalla-Epithelioid Sarcoma-BJ, VAESBJ

🤖 AI SummaryBased on 9 publications

Quick Overview

Human epithelioid sarcoma cell line with SMARCB1 loss and complex genomic alterations.

Detailed Summary

VA-ES-BJ is a human epithelioid sarcoma cell line derived from a bone marrow aspirate of a 41-year-old male patient. It exhibits epithelioid morphology with features of both mesenchymal and epithelial differentiation, including expression of vimentin and cytokeratins. The cell line demonstrates chromosomal abnormalities, including triploidy and marker chromosomes, and shows rapid growth in nude mice. It secretes immunoreactive GM-CSF and exhibits sensitivity to epidermal growth factor. VA-ES-BJ has been used in studies investigating the molecular mechanisms of epithelioid sarcoma, including the role of SMARCB1 loss and genomic instability. Research has also explored its potential as a model for studying tumor progression and therapeutic responses.

Research Applications

Molecular mechanisms of epithelioid sarcomaSMARCB1 loss and genomic instabilityTumor progression and therapeutic responses

Key Characteristics

Epithelioid morphologyVimentin and cytokeratin expressionChromosomal abnormalitiesRapid growth in nude miceGM-CSF secretionSensitivity to epidermal growth factor

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1785
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	41
Age Category	Adult
Sex	Male

Disease Information

Disease	Epithelioid sarcoma
Lineage	Soft Tissue
Subtype	Epithelioid Sarcoma
OncoTree Code	EPIS

DepMap Information

Source Type	ATCC
Source ID	ACH-001702_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	NF2	p.Ser87Ter (c.260C>A)	Homozygous	-	from parent cell line VA-ES-BJ

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

11,12

D16S539

11,12

D18S51

12,13

D19S433

D21S11

27,28

D2S1338

16,17

D3S1358

D5S818

11,13

D7S820

11,12

D8S1179

FGA

Penta D

7,10,13

Penta E

TH01

TPOX

vWA

18,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters.

Irizarry R.A., Zhao K.-J., Ranish J.A., Kadoch C.

Nat. Genet. 49:1613-1623(2017).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

The genomic landscape of epithelioid sarcoma cell lines and tumours.

Nielsen T.O.

J. Pathol. 238:63-73(2016).

DOI PubMed

Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.

Harris E., Monks A., Morris J.

Mol. Cancer Ther. 14:2452-2462(2015).

DOI PubMed PMC

VA-ES-BJ -- an epithelioid sarcoma cell-line.";

Helson L.

Int. J. Oncol. 7:51-56(1995).

DOI PubMed

Epithelioid sarcoma and unclassified sarcoma with epithelioid features: clinicopathological variables, molecular markers, and a new experimental model.

Hornick J.L., Lazar A.J.F., Pollock R.E., Lev D.C.

Oncologist 16:512-522(2011).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed

Web Resources

tcpaportal.org