VMRC-MELGHomo sapiens (Human)Cancer cell line
Also known as: Virginia Mason Research Center-Melanoma G, Leggee, VMRCMELG
🤖 AI SummaryBased on 2 publications
Quick Overview
Human melanoma cell line for cancer research.
Detailed Summary
The VMRC-MELG cell line is derived from a human melanoma, providing a valuable model for studying melanoma biology and therapeutic strategies. While specific details about its tissue origin, disease characteristics, and cell type are not explicitly provided, the cell line is utilized in cancer research to investigate genetic and molecular mechanisms underlying melanoma progression. Its applications include drug screening, gene expression analysis, and understanding tumor heterogeneity. Further characterization may be required to fully elucidate its properties and potential in cancer studies.
Research Applications
Cancer researchDrug screeningGene expression analysisTumor heterogeneity studies
Key Characteristics
Human-derivedMelanoma cell line
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1789 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001704_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | CDKN2A | c.151-1G>A | Homozygous | Splice acceptor mutation | Unknown, Unknown |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
8,11
D16S539
12
D18S51
15,18
D21S11
27,32.2
D3S1358
14,16
D5S818
10,13
D7S820
8,10
D8S1179
14
FGA
19,23
Penta D
10,12
Penta E
5
TH01
6,7
TPOX
9,11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).