VMRC-RCWHomo sapiens (Human)Cancer cell line

Also known as: Virginia Mason Research Center-Renal Cancer W, Thomas Wirts, VMRCRCW

🤖 AI SummaryBased on 6 publications

Quick Overview

Renal cell carcinoma cell line with potential for research in cancer genomics and drug sensitivity.

Detailed Summary

VMRC-RCW is a renal cell carcinoma (RCC) cell line derived from human tissue. It is part of a large panel of RCC cell lines used to study the genomic and molecular characteristics of kidney cancers. Research on VMRC-RCW has focused on understanding the genetic alterations and copy number variations that contribute to RCC progression. This cell line has been utilized in studies examining the relationship between genomic profiles and drug sensitivity, particularly in the context of targeted therapies. VMRC-RCW is noted for its specific genetic features, including the absence of 3p loss, which is a common feature in many RCC cell lines. This characteristic may influence its utility in studies related to tumor biology and therapeutic response. The cell line's genetic profile provides insights into the heterogeneity of RCC and aids in the development of personalized treatment strategies.

Research Applications

Genomic profiling of renal cell carcinomaDrug sensitivity testingCopy number variation analysisMolecular characterization of tumor biology

Key Characteristics

Absence of 3p lossPotential for studying tumor heterogeneityRelevance to renal cancer genomics

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1790
Species	Homo sapiens (Human)

Donor Information

Age Category	Unknown
Sex	Male

Disease Information

Disease	Renal cell carcinoma
Lineage	Kidney
Subtype	Renal Cell Carcinoma
OncoTree Code	RCC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000484_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

D16S539

11,15

D18S51

15,16

D19S433

D21S11

32.2,33.2

D2S1338

21,22

D3S1358

D5S818

D7S820

8,10

D8S1179

FGA

21,22

Penta D

9,11

Penta E

11,12

TH01

6,9.3

TPOX

vWA

14,15

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.

Hsieh J.J.-D., Hakimi A.A.

Nat. Commun. 8:15165.1-15165.10(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines.

Nakatani Y., Hosaka M.

Int. J. Cancer 91:219-224(2001).

DOI PubMed

Expression of the SART1 tumor rejection antigen in renal cell carcinoma.

Yoshizumi O., Itoh K.

Urol. Res. 28:178-184(2000).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed