YH-13Homo sapiens (Human)Cancer cell line

Also known as: YH, YH13

🤖 AI SummaryBased on 7 publications

Quick Overview

Human glioblastoma cell line with known MGMT activity and chemosensitivity profiles.

Detailed Summary

The YH-13 cell line is a human glioblastoma-derived cell line established from a 49-year-old male patient with a frontoparietal glioblastoma. It exhibits a fibroblastic growth pattern in culture and expresses glial fibrillary acidic protein (GFAP) and S-100 protein, indicating an astrocytic origin. YH-13 demonstrates high O6-methylguanine-DNA methyltransferase (MGMT) activity, which correlates with resistance to chloroethylnitrosourea (ACNU) chemotherapy. This cell line has been used to study the relationship between MGMT expression and chemosensitivity in glioblastoma, providing insights into the mechanisms of drug resistance. YH-13 has been passaged over 50 times and maintains consistent morphological and immunohistochemical characteristics, making it a valuable model for investigating glioblastoma biology and therapeutic responses.

Research Applications

Chemosensitivity testingMGMT activity analysisDrug resistance mechanismsTumor biology studies

Key Characteristics

High MGMT activityFibroblastic growth patternGFAP and S-100 expressionResistance to ACNU

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1795
Species	Homo sapiens (Human)
Tissue Source	Brain, left fronto-parietal lobe

Donor Information

Age	40
Age Category	Adult
Sex	Male

Disease Information

Disease	Glioblastoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	HSRRB
Source ID	ACH-000469_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Phe113Val (c.337T>G)	Homozygous	-	Unknown, Unknown
MutationSimple	PIK3CA	p.Gln75Glu (c.223C>G)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

9,12

D16S539

D5S818

10,12

D7S820

8,12

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Aoyagi M., Ohno K., Imoto I., Inazawa J.

Cancer Sci. 96:676-683(2005).

DOI PubMed PMC

Characterization and chemosensitivity of two cell lines derived from human glioblastomas.

Izumu I., Mineura K., Watanabe K., Kowada M.

J. Neurooncol. 17:111-121(1993).

DOI PubMed

Establishment of the two glioma cell lines: YH and AM.";

Izumi I., Mineura K., Watanabe K., Kowada M.

Hum. Cell 7:101-105(1994).

PubMed

Brain tumors.";

Ali-Osman F.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).

DOI