42-MG-BAHomo sapiens (Human)Cancer cell line

Also known as: 42MGBA

🤖 AI SummaryBased on 5 publications

Quick Overview

Human cancer cell line with potential for cancer research and drug development.

Detailed Summary

The 42-MG-BA cell line is a human cancer cell line derived from a glioblastoma multiforme (GBM) tumor. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies related to cancer genomics and drug sensitivity. This cell line is notable for its PTEN mutations, which have been corrected through gene editing techniques, providing insights into the role of PTEN in cancer progression. The cell line has been utilized in research to understand the effects of PTEN correction on cellular proliferation and Akt signaling pathways. Additionally, it has been part of studies examining the impact of HLA types and neo-epitopes on cancer immunotherapy. The 42-MG-BA cell line is also used in investigations of viral infections and their potential role in cancer development.

Research Applications

Cancer genomicsDrug sensitivity profilingPTEN mutation correction studiesImmunotherapy researchViral infection studies

Key Characteristics

PTEN mutationsGene editing applicationsHLA type analysisNeo-epitope predictionViral detection

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1798
Species	Homo sapiens (Human)
Tissue Source	Brain, temporal lobe[UBERON:UBERON_0001871]

Donor Information

Age	63
Age Category	Adult
Sex	Male

Disease Information

Disease	Glioblastoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	DSMZ
Source ID	ACH-000323_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg282Gln (c.845G>A)	Heterozygous	-	Unknown, Unknown
MutationSimple	TP53	p.Thr211Ile (c.632C>T)	Unspecified	-	PubMed=8253536
MutationSimple	PTEN	c.164+1_164+2insG	Heterozygous	Causes aberrant splicing	Unknown, PubMed=28464039

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

D16S539

D18S51

D19S433

D21S11

D2S1338

D3S1358

D5S818

11,12

D7S820

D8S1179

FGA

Penta D

12,14

Penta E

7,17

TH01

6,8

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Correction of PTEN mutations in glioblastoma cell lines via AAV-mediated gene editing.

Hill V.K., Kim J.-S., James C.D., Waldman T.

PLoS ONE 12:E0176683-E0176683(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Characterization of two new permanent glioma cell lines 8-MG-BA and 42-MG-BA.

Perzelova A., Macikova I., Mraz P., Bizik I., Steno J.

Neoplasma 45:25-29(1998).

PubMed