CAL-78Homo sapiens (Human)Cancer cell line
Also known as: Centre Antoine Lacassagne-78, CAL78, CAL 78
🤖 AI SummaryBased on 4 publications
Quick Overview
CAL-78 is a human chondrosarcoma cell line derived from a dedifferentiated tumor, used for cancer research and drug development.
Detailed Summary
CAL-78 is a human chondrosarcoma cell line established from a dedifferentiated chondrosarcoma of the thigh muscle. It exhibits fibroblastoid morphology and expresses vimentin, indicating a mesodermal origin. The cell line forms xenografts with hyaline cartilage differentiation, making it a valuable model for studying chondrosarcoma biology and evaluating therapeutic strategies. CAL-78 has a complex karyotype with tetraploid metaphases, and it is used in research to understand tumor progression and response to treatments. Its characteristics make it suitable for in vitro studies on chondrocyte differentiation and cancer therapeutics.
Research Applications
Cancer researchDrug developmentTumor biology studiesChondrocyte differentiation research
Key Characteristics
Fibroblastoid morphologyVimentin expressionXenograft formation with cartilage differentiationComplex karyotypeTetraploid metaphases
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1809 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Thigh, skeletal muscle[UBERON:UBERON_0004252] |
Donor Information
| Age | 76 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Chondrosarcoma |
|---|---|
| Lineage | Bone |
| Subtype | Dedifferentiated Chondrosarcoma |
| OncoTree Code | DDCHS |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000516_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Glu286_Glu287del (c.856_861delCTCTTC) | Unspecified | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
8,12
D16S539
8,11
D18S51
11,15
D19S433
13,15
D21S11
30,32.2
D2S1338
17
D3S1358
18
D5S818
11,12
D7S820
11
D8S1179
13
FGA
19
Penta D
11,12
Penta E
11,13
TH01
6
TPOX
8
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).