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HPB-ALLHomo sapiens (Human)Cancer cell line

Also known as: FCCH1018, HPBALL, HPB/ALL

🤖 AI SummaryBased on 14 publications

Quick Overview

Human T-cell acute lymphoblastic leukemia cell line with known genetic alterations.

Detailed Summary

HPB-ALL is a human T-cell acute lymphoblastic leukemia (T-ALL) cell line derived from a 14-year-old male patient. It is characterized by specific genetic alterations, including the t(5;14)(q35;q32.2) translocation, which involves the HOXI IL2 and BCL1 IB genes. This cell line has been extensively studied for its role in understanding the molecular mechanisms of T-ALL, particularly in relation to gene expression and chromosomal abnormalities. HPB-ALL is used in research to investigate the pathogenesis of T-ALL and to develop targeted therapies. The cell line exhibits a distinct immunophenotype, including expression of CD1, CD2, CD3, CD4, CD5, CD6, CD7, CD8, CD10, CD13, CD19, CD21, CD34, CD38, HLA-DR, and TCRα/β and TCRγ/δ. It is also noted for its utility in studying the effects of genetic mutations on cell proliferation and differentiation.

Research Applications

Molecular mechanisms of T-ALLGene expression analysisChromosomal abnormalities in leukemiaDevelopment of targeted therapiesImmunophenotyping studies

Key Characteristics

t(5;14)(q35;q32.2) translocationHOXI IL2 and BCL1 IB gene involvementDistinct immunophenotypeUsed in cancer research and drug development
Generated on 6/17/2025

Basic Information

Database IDCVCL_1820
SpeciesHomo sapiens (Human)
Tissue SourcePeripheral blood[UBERON:UBERON_0000178]

Donor Information

Age14
Age CategoryPediatric
SexMale
Raceasian
Subtype FeaturesTLX3

Disease Information

DiseasePrecursor T-cell acute lymphoblastic leukemia
LineageLymphoid
SubtypeT-Lymphoblastic Leukemia/Lymphoma
OncoTree CodeTLL

DepMap Information

Source TypeDSMZ
Source IDACH-000942_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleWT1p.Ser121Ter (c.362C>A)Heterozygous-Unknown, PubMed=22675565
MutationSimpleTP53p.Arg273Cys (c.817C>T)Homozygous-PubMed=35933914
MutationSimpleTP53p.Cys124Ter (c.372C>A)Homozygous-from parent cell line HPB-MLT
MutationSimplePTENp.Arg159Ser (c.477G>T)Homozygous-Unknown
MutationSimpleNOTCH1p.Asp2442fs*39 (c.7326_7326insGGGCCGTGGACG)Heterozygous-from parent cell line HPB-MLT
MutationSimpleNOTCH1p.Leu1574Pro (c.4721T>C)Heterozygous-from parent cell line PF-382
MutationSimpleHRASp.Ala134Ser (c.400G>T)Unspecified-PubMed=22675565
MutationSimpleFBXW7p.Arg465His (c.1394G>A)Homozygous-Unknown, PubMed=26870252, PubMed=22675565
Gene fusionCBFBCBFB-MYL11, CBFB-MYLPF--from parent cell line HPB-MLT

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
10,11
D13S317
8,10
D16S539
9,11
D18S51
15,19
D19S433
13,14
D21S11
30
D2S1338
21
D3S1358
17
D5S818
11
D7S820
11
D8S1179
11,12
FGA
19,23
Penta D
9,11
Penta E
10,15
TH01
7,9
TPOX
8,12
vWA
18,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOIPubMedPMC

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOIPubMedPMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOIPubMedPMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOIPubMedPMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOIPubMedPMC

High accuracy mutation detection in leukemia on a selected panel of cancer genes.

Cools J., Aerts S.

PLoS ONE 7:E38463-E38463(2012).

DOIPubMedPMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Langerak A.W.

Leukemia 21:230-237(2007).

DOIPubMed

Analysis of p53 status in human cell lines using a functional assay in yeast: detection of new non-sense p53 mutation in codon 124.

Smardova J., Pavlova S., Svitakova M., Grochova D., Ravcukova B.

Oncol. Rep. 14:901-907(2005).

DOIPubMed

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.

Science 306:269-271(2004).

DOIPubMed

Activation of HOX11L2 by juxtaposition with 3'-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2).

MacLeod R.A.F., Nagel S., Kaufmann M., Janssen J.W.G., Drexler H.G.

Genes Chromosomes Cancer 37:84-91(2003).

DOIPubMed

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

DOIPubMed

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

DOIPubMed

Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.

Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.

Leuk. Res. 23:19-27(1999).

DOIPubMed

Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.

Aizawa Y., Ueda R., Seto M.

Jpn. J. Cancer Res. 89:712-718(1998).

DOIPubMedPMC

Frameshift mutations of the hMSH6 gene in human leukemia cell lines.

Hirai H.

Jpn. J. Cancer Res. 89:33-39(1998).

DOIPubMedPMC

Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.

Liu C., Kondo E., Minowada J., Akagi T.

Jpn. J. Cancer Res. 87:1070-1077(1996).

DOIPubMedPMC

p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.

Einhorn S.

Eur. J. Haematol. 56:313-318(1996).

DOIPubMed

Interferon system defects in malignant T-cells.";

Xu B., Einhorn S.

Leukemia 8:425-434(1994).

PubMed

Carcinoembryonic antigen producing cultured cell lines enable detection of autoantibodies in sera from patients with gastrointestinal cancer.

Ikeda S., Soeda S., Fujimura M.

Cancer 50:1775-1782(1982).

DOIPubMed

Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.

Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.

Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).

DOIPubMedPMC

Antigens specific for human T-lymphocytes detected by xenoantisera to HD-MAR cells: their differential expression on various T-cell lines.

Schlesinger M.

Hum. Immunol. 4:219-228(1982).

DOIPubMed

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

DOIPubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

DOIPubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

DOIPubMed

Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.

Nakano A., Harada T., Morikawa S., Kato Y.

Acta Pathol. Jpn. 40:107-115(1990).

DOIPubMed

Characterization of three T-lymphoid cell lines with distinct sensitivities to deoxyadenosine plus deoxycoformycin.

Duan D.-S., Smith W., Sadee W., Cowan M.J.

Thymus 19:1-11(1992).

PubMed

Two E-rosette-forming lymphoid cell lines.";

Morikawa S., Tatsumi E., Baba M., Harada T., Yasuhira K.

Int. J. Cancer 21:166-170(1978).

DOIPubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

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