LA-N-2Homo sapiens (Human)Cancer cell line

Also known as: LAN2, LAN-2

🤖 AI SummaryBased on 4 publications

Quick Overview

Human neuroblastoma cell line with ALK mutations and high tumorigenicity.

Detailed Summary

LA-N-2 is a human neuroblastoma cell line derived from a primary tumor. It is characterized by the presence of ALK mutations, which are associated with advanced stages of neuroblastoma. These mutations lead to increased kinase activity and are implicated in the pathogenesis of the disease. LA-N-2 exhibits high tumorigenicity, forming tumors in nude mice, and shows significant sensitivity to ALK inhibitors. The cell line is also noted for its ability to undergo bidirectional differentiation, suggesting a stem cell-like property. Research on LA-N-2 has contributed to understanding the role of ALK mutations in neuroblastoma and the potential for targeted therapies.

Research Applications

ALK mutation analysisTumorigenicity studiesDrug sensitivity testingDifferentiation studies

Key Characteristics

ALK mutationsHigh tumorigenicityBidirectional differentiationSensitivity to ALK inhibitors

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1829
Species	Homo sapiens (Human)

Donor Information

Age	3
Age Category	Pediatric
Sex	Female
Subtype Features	MYC_Amplified

Disease Information

Disease	Neuroblastoma
Lineage	Peripheral Nervous System
Subtype	Neuroblastoma
OncoTree Code	NBL

DepMap Information

Source Type	DSMZ
Source ID	ACH-001354_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg337Cys (c.1009C>T)	Unspecified	-	PubMed=32321971

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

11,12

D16S539

9,10

D18S51

15,18

D19S433

D21S11

29,30

D2S1338

D3S1358

D5S818

11,12

D7S820

8,10

D8S1179

13,15

FGA

20,22

Penta D

11,12

Penta E

11,17

TH01

9.3

TPOX

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.

Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.

Transl. Oncol. 6:685-696(2013).

DOI PubMed PMC

Oncogenic mutations of ALK kinase in neuroblastoma.";

Hayashi Y., Mano H., Ogawa S.

Nature 455:971-974(2008).

DOI PubMed

Characteristics of stem cells from human neuroblastoma cell lines and in tumors.

Biedler J.L., Cheung N.-K.V., Ross R.A.

Neoplasia 6:838-845(2004).

DOI PubMed PMC

Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.

Reynolds C.P., Reynolds D.A., Frenkel E.P., Smith R.G.

Cancer Res. 42:1331-1336(1982).

PubMed

Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines.

Neustein H.B., Benedict W.F.

Cancer Res. 37:1364-1371(1977).

PubMed

Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.

Biedler J.L., Meyers M.B., Spengler B.A.

(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff S., Hertz L. (eds.); pp.267-307; Academic Press; New York; USA (1983).

DOI

Neuroblastoma.";

Thiele C.J.

(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).

DOI