NALM-16Homo sapiens (Human)Cancer cell line

Also known as: Nalm-16, NALM16

🤖 AI SummaryBased on 8 publications

Quick Overview

Human B-cell precursor leukemia cell line with unique characteristics for research.

Detailed Summary

NALM-16 is a human B-cell precursor leukemia cell line established from a patient with acute lymphoblastic leukemia (ALL). It is characterized by its expression of specific surface markers such as HLA-DR, CD22, and CD79a, and it is negative for surface immunoglobulin (Ig). The cell line exhibits a complex karyotype with various chromosomal abnormalities, including the Philadelphia chromosome (Ph) and other translocations. NALM-16 is used in research for studying B-cell differentiation, leukemia biology, and drug development. It has been utilized in studies involving microsatellite instability and mutations in genes like BAX, TGFβRI, and hMSH6. The cell line is also noted for its ability to maintain certain genetic features over time, making it a valuable tool for long-term studies.

Research Applications

B-cell differentiation studiesLeukemia biology researchDrug development and testingMicrosatellite instability analysisGenetic mutation studies

Key Characteristics

Expresses HLA-DR, CD22, and CD79aNegative for surface immunoglobulin (Ig)Complex karyotype with chromosomal abnormalitiesPhiladelphia chromosome (Ph) presenceUtilized in studies of BAX, TGFβRI, and hMSH6 mutations

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1834
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	12
Age Category	Pediatric
Sex	Female
Subtype Features	Near haploid

Disease Information

Disease	Precursor B-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma with Hypodiploidy
OncoTree Code	BLLHYPO

DepMap Information

Source Type	DSMZ
Source ID	ACH-001993_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D18S51

17,18

D19S433

D21S11

29,30

D2S1338

D3S1358

15,17

D5S818

D7S820

D8S1179

FGA

Penta D

9,12.4

Penta E

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOI PubMed PMC

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

DOI PubMed

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

DOI PubMed

Establishment and characterization of human B cell precursor-leukemia cell lines.

Matsuo Y., Drexler H.G.

Leuk. Res. 22:567-579(1998).

DOI PubMed

Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines.

Nakamura H., Amakawa R., Ohno H.

Leukemia 10:1592-1603(1996).

PubMed

Chromosome evolution of near-haploid clones in an established human acute lymphoblastic leukemia cell line (NALM-16).

Kohno S.-i., Minowada J., Sandberg A.A.

J. Natl. Cancer Inst. 64:485-493(1980).

DOI PubMed

Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.

Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.

Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).

DOI PubMed PMC

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

DOI PubMed

Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.

Nakano A., Harada T., Morikawa S., Kato Y.

Acta Pathol. Jpn. 40:107-115(1990).

DOI PubMed

Use of stimulating capacity of mixed lymphocyte reaction (MLR-S) as a possible marker for the cell-origin of null-cell acute lymphoblastic leukaemia.

Han T., Minowada J.

Immunology 35:333-339(1978).

PubMed PMC

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI