NALM-19Homo sapiens (Human)Cancer cell line

Also known as: Nalm19, NALM19

🤖 AI SummaryBased on 4 publications

Quick Overview

Human B-cell precursor leukemia cell line for cancer research.

Detailed Summary

NALM-19 is a human B-cell precursor leukemia cell line derived from a 26-year-old male patient with acute undifferentiated leukemia (AUL). This cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been characterized for its immunological, molecular, and cytogenetic features. NALM-19 exhibits typical B-cell lineage markers such as HLA-DR, CD22, and CD79a, but lacks surface immunoglobulin (Ig). It is negative for surface immunoglobulin and shows specific chromosomal abnormalities associated with B-cell precursor leukemias, including translocations involving the MLL-AF4, BCR-ABL, ENL-MLL, TEL/ETV6-AML1, and E2A-HLL fusion genes. NALM-19 is used in studies related to leukemia biology, drug sensitivity, and molecular mechanisms of cancer progression.

Research Applications

Leukemia biologyDrug sensitivity profilingMolecular mechanisms of cancer progression

Key Characteristics

Expresses B-lineage markers (HLA-DR, CD22, CD79a)Lacks surface immunoglobulin (Ig)Carries chromosomal translocations associated with B-cell precursor leukemias

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1835
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	26
Age Category	Adult
Sex	Male

Disease Information

Disease	Precursor B-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma
OncoTree Code	BLL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000130_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

9,10

D13S317

8,12

D16S539

11,13

D18S51

15,17.3

D19S433

D21S11

30,31

D2S1338

19,25

D3S1358

16,18

D5S818

10,11

D7S820

10,11

D8S1179

13,14

FGA

21,23

Penta D

Penta E

15,17

TH01

TPOX

8,11

vWA

17,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Establishment and characterization of human B cell precursor-leukemia cell lines.

Matsuo Y., Drexler H.G.

Leuk. Res. 22:567-579(1998).

DOI PubMed

Establishment and characterization of a bi-phenotypic leukemic cell line, NALM-19, from a patient with acute leukemia.

Minowada J.

Hum. Cell 4:257-260(1991).

PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI