PaCaDD-119Homo sapiens (Human)Cancer cell line
Also known as: PACADD119, PACADD-119
🤖 AI SummaryBased on 1 publications
Quick Overview
Human pancreatic cancer cell line for research on PDAC biology and therapies.
Detailed Summary
PaCaDD-119 is a human pancreatic ductal adenocarcinoma (PDAC) cell line established using the Dresden outgrowth method. It exhibits epithelial-like morphology with a cobblestone pattern and forms colonies on matrigel with dome formation. The cell line has a doubling time of 47.45 hours and shows nuclear p53 accumulation in over half of its cells. KRAS mutations are present, consistent with the primary tumor from which it was derived. PaCaDD-119 demonstrates infiltrative growth characteristics and continues to divide indefinitely, making it a valuable tool for studying PDAC progression and therapeutic strategies.
Research Applications
Cancer biology researchPancreatic cancer drug developmentTumor progression studies
Key Characteristics
Epithelial-like morphologyInfiltrative growthKRAS mutationIndefinite proliferationNuclear p53 accumulation
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1848 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pancreas, head[UBERON:UBERON_0001069] |
Donor Information
| Age | 59 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Pancreatic adenocarcinoma |
|---|---|
| Lineage | Pancreas |
| Subtype | Pancreatic Adenocarcinoma |
| OncoTree Code | PAAD |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001375_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys238Tyr (c.713G>A) | Unspecified | - | PubMed=12037578 |
| MutationSimple | KRAS | p.Gly12Ala (c.35G>C) | Unspecified | - | PubMed=21173094 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
13
D16S539
9,12
D18S51
16
D19S433
13,14
D21S11
28
D2S1338
17,25
D3S1358
15,17
D5S818
12,13
D7S820
10,12
D8S1179
10
FGA
21,22
Penta D
10
Penta E
9,12
TH01
7
TPOX
8
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Five primary human pancreatic adenocarcinoma cell lines established by the outgrowth method.
Krautz C., Hering S., Saeger H.-D., Grutzmann R., Pilarsky C.
J. Surg. Res. 172:29-39(2012).
Distribution of characteristic mutations in native ductal adenocarcinoma of the pancreas and pancreatic cancer cell lines.
Saeger H.-D.
Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013).