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RCH-ACVHomo sapiens (Human)Cancer cell line

Also known as: RCH, RCHACV, RCH-AVC (Prior to 2020.)

🤖 AI SummaryBased on 11 publications

Quick Overview

RCH-ACV is a pre-B cell leukemia cell line with t(1;19) translocation and trisomy 8.

Detailed Summary

RCH-ACV is a pre-B cell leukemia cell line established from a child with acute lymphoblastic leukemia (ALL). It exhibits a t(1;19) translocation, which is associated with poor prognosis in pre-B ALL. The cell line also shows trisomy 8, a chromosomal abnormality often seen in leukemias. RCH-ACV has been used in studies to investigate the molecular mechanisms of leukemia, including the role of the E2A-PBX1 fusion gene and its impact on gene expression. Research on this cell line has contributed to understanding the genetic basis of leukemia and the development of targeted therapies.

Research Applications

Study of t(1;19) translocation in pre-B ALLInvestigation of E2A-PBX1 fusion geneAnalysis of chromosomal abnormalities in leukemiaDevelopment of targeted therapies for leukemia

Key Characteristics

t(1;19) translocationTrisomy 8Pre-B cell originExpression of E2A-PBX1 fusion gene

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1851
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	8
Age Category	Pediatric
Sex	Female
Subtype Features	TCF3-PBX1

Disease Information

Disease	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1
OncoTree Code	BLLTCF3PBX1

DepMap Information

Source Type	DSMZ
Source ID	ACH-000922_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	NSD2	p.Glu1099Lys (c.3295G>A)	Heterozygous	-	PubMed=35124168
MutationSimple	KRAS	p.Val14Ile (c.40G>A)	Heterozygous	-	Unknown, Unknown
MutationSimple	HRAS	p.Ala11Thr (c.31G>A)	Heterozygous	-	Unknown, Unknown
MutationSimple	EGFR	p.Arg677Cys (c.2029C>T)	Heterozygous	-	Unknown, Unknown
Gene fusion	PBX1	TCF3-PBX1, E2A-PBX1	-	-	PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,11

D13S317

9,14

D16S539

11

D18S51

13,16

D19S433

14

D21S11

29,31.2

D2S1338

17,18

D3S1358

15

D5S818

11,12

D7S820

10,11

D8S1179

13,15

FGA

23,26

Penta D

9,10

Penta E

7,11

TH01

6,8

TPOX

8,11

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.

Minegishi M., Iwamoto S., Sugita K., Inukai T.

J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.

Sugita K., Hosoi H.

Int. J. Hematol. 108:312-318(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.

Dexter T.J., Ashworth A., Kearney L.

Genes Chromosomes Cancer 45:554-564(2006).

Real-time reverse transcription polymerase chain reaction detection and quantification of t(1;19) (E2A-PBX1) fusion genes associated with leukaemia.

Curry J.D., Glaser M.C., Smith M.T.

Br. J. Haematol. 115:826-830(2001).

EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.

Fu X.-Y., McGrath S., Pasillas M., Nakazawa S., Kamps M.P.

Oncogene 18:4920-4929(1999).

Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.

Janssen J.W.G., Drexler H.G.

Leukemia 11:441-447(1997).

RCH-ACV: a lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8.

Morley A.A.

Cancer Genet. Cytogenet. 19:261-269(1986).

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.

Smith S.D., Cleary M.L.

Cell 60:535-545(1990).

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

Rowley J.D., Diaz M.O.

Proc. Natl. Acad. Sci. U.S.A. 88:10735-10739(1991).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).