TanoueHomo sapiens (Human)Cancer cell line

Also known as: TANOUE

🤖 AI SummaryBased on 6 publications

Quick Overview

Human B-lineage acute lymphoblastic leukemia cell line with potential for mixed lineage characteristics.

Detailed Summary

The Tanoue cell line, derived from a B-lineage acute lymphoblastic leukemia (ALL) patient, is notable for its expression of myeloid surface antigens and the ability to respond to granulocyte colony-stimulating factor (G-CSF). This cell line has been used to study the effects of G-CSF receptor expression on myeloid differentiation and proliferation. Research indicates that exogenous expression of the G-CSF receptor can induce myeloid characteristics in ALL cells, suggesting potential applications in understanding mixed lineage leukemias. The cell line has also been utilized to investigate the relationship between G-CSF receptor expression and cell responsiveness to G-CSF in terms of proliferation and differentiation.

Research Applications

Study of G-CSF receptor function in leukemiaInvestigation of mixed lineage leukemia characteristicsAnalysis of myeloid differentiation in B-cell ALLEvaluation of G-CSF responsiveness in leukemic cells

Key Characteristics

Expression of myeloid surface antigensAbility to respond to G-CSFPotential for mixed lineage characteristicsExogenous G-CSF receptor expression induces myeloid features

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1852
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	11
Age Category	Pediatric
Sex	Male
Subtype Features	BCL2/MYC

Disease Information

Disease	Precursor B-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma
OncoTree Code	BLL

DepMap Information

Source Type	DSMZ
Source ID	ACH-001669_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Met246Thr (c.737T>C)	Heterozygous	-	Unknown, PubMed=15901131

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

11,12

D16S539

10,12,13,14

D18S51

13,14

D19S433

15,16

D21S11

29,30

D2S1338

18,19

D3S1358

15,16

D5S818

10,11,12

D7S820

10,11

D8S1179

14,15

FGA

19,22,23

Penta D

11,13

Penta E

14,18,19

TH01

7,10

TPOX

vWA

14,18,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.

Vettorazzi E., Bokemeyer C., Dierlamm J.

Genes Chromosomes Cancer 53:497-515(2014).

DOI PubMed

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOI PubMed

Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.

Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.

Pathol. Res. Pract. 201:109-115(2005).

DOI PubMed

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

DOI PubMed

Exogenous expression of human granulocyte colony-stimulating factor receptor in a B-lineage acute lymphoblastic leukemia cell line: a possible model for mixed lineage leukemia.

Shimosaka A., Matsuda I.

Leuk. Res. 19:249-256(1995).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

tcpaportal.org