UCSD-AML1Homo sapiens (Human)Cancer cell line
Also known as: UCSD/AML 1, UCSD/AML-1, UCSD/AML1, UCSC-AML1
🤖 AI SummaryBased on 1 publications
Quick Overview
Human cell line with B-ALL characteristics and MN1-TEL fusion.
Detailed Summary
The UCSD-AML1 cell line is derived from a human patient with B-cell acute lymphoblastic leukemia (B-ALL). It carries the MN1-TEL fusion gene, resulting from the chromosomal translocation t(12;22)(p13;q11). This fusion is associated with transcriptional activation and transformation properties, making it a valuable model for studying leukemogenesis. The cell line was used in research to investigate the biological effects of the MN1-TEL fusion protein, which exhibits strong transcriptional activation and transformation capabilities. The UCSD-AML1 cell line has been utilized in studies focusing on the mechanisms of TEL gene fusion proteins and their role in hematopoietic malignancies. It is also relevant for understanding the pathogenesis of leukemias and myelodysplastic syndromes involving TEL gene rearrangements.
Research Applications
Study of MN1-TEL fusion proteinInvestigation of TEL gene rearrangementsAnalysis of leukemogenesis mechanismsResearch on hematopoietic malignancies
Key Characteristics
MN1-TEL fusion genet(12;22)(p13;q11) chromosomal translocationExpression of MN1-TEL fusion proteinTranscriptional activation propertiesTransformation capabilities
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1853 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 73 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Acute myeloid leukemia with inv3(q21;q26.2) or t(3;3)(q21;q26.2) |
|---|---|
| Lineage | Myeloid |
| Subtype | Acute Myeloid Leukemia |
| OncoTree Code | AML |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001684_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,12
D13S317
11,12
D16S539
8,12
D18S51
12,17
D19S433
14
D21S11
29,30
D2S1338
19,20
D3S1358
14,18
D5S818
10,12
D7S820
11
D8S1179
11
FGA
20,22
Penta D
11
Penta E
9,17
TH01
7,8
TPOX
8,9
vWA
15,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Expression of the MN1-TEL fusion protein in the human UCSD/AML1 leukemic cell line.
Bernard O.A.
Leukemia 18:1558-1560(2004).
Characterization of a factor-dependent acute leukemia cell line with translocation (3;3)(q21;q26).
Oval J., Jones O.W., Montoya M., Taetle R.
Blood 76:1369-1374(1990).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).