ULAHomo sapiens (Human)Cancer cell line
Also known as: Uppsala Lymphoma Ascites-fluid
🤖 AI SummaryBased on 2 publications
ULA Cell Line
Quick Overview
Human B-cell lymphoma cell line with double-hit features for cancer research.
Detailed Summary
The ULA cell line is a human B-cell lymphoma model derived from a chemotherapy-resistant diffuse large B-cell lymphoma (DLBCL) patient. It exhibits a complex karyotype with multiple chromosomal abnormalities, including a t(14;18)(q32;q21) translocation involving the BCL2 gene and a loss of the p53 gene. ULA cells display a B-cell phenotype, expressing markers such as CD10, CD19, CD20, and Bcl-2, while being negative for T-cell markers. The cell line requires specific culture conditions, including Matrigel-coated surfaces for survival, and shows resistance to multiple chemotherapeutic agents. It is used in research to study mechanisms of drug resistance and genetic alterations in DLBCL.
Research Applications
Study of double-hit B-cell lymphomasInvestigation of chemotherapy resistance mechanismsAnalysis of genetic alterations in DLBCL
Key Characteristics
Complex karyotype with multiple chromosomal aberrationst(14;18)(q32;q21) translocation involving BCL2Loss of p53 geneB-cell phenotype with specific surface markersResistance to multiple chemotherapeutic drugs
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1854 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Donor Information
| Age | 57 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Diffuse large B-cell lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Diffuse Large B-Cell Lymphoma, NOS |
| OncoTree Code | DLBCLNOS |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001686_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
9,10
D13S317
9,12
D16S539
11,12
D18S51
12,17
D19S433
14,16
D21S11
30,31
D2S1338
23,25
D3S1358
16
D5S818
11,12
D7S820
11
D8S1179
13
FGA
19,21
Penta D
9,12
Penta E
7
TH01
9.3
TPOX
8,10
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Leuk. Lymphoma 57:1015-1020(2016).