UPCI-SCC-029AHomo sapiens (Human)Cancer cell line
Also known as: SCC029, UPCI:SCC029, UPCI:SCC029B, UPCI-SCC-029B, UPCISCC029A, UPCI:SCC029A, UPCI-SCC-29A
🤖 AI SummaryBased on 3 publications
Quick Overview
Human oral squamous cell carcinoma cell line with 11q13 amplification and chromosomal instability.
Detailed Summary
UPCI-SCC-029A is a human oral squamous cell carcinoma (OSCC) cell line derived from a primary tumor. It exhibits significant chromosomal instability, including aneuploidy and structural abnormalities. This cell line is characterized by amplification of the 11q13 region, which is associated with poor prognosis and increased tumor aggressiveness. The 11q13 amplification includes the cyclin D1 (CCND1) gene and is linked to enhanced cell proliferation and resistance to DNA damage. UPCI-SCC-029A has been used in studies to investigate the role of the ATR-CHEK1 pathway in radioresistance and DNA repair mechanisms. It is also a valuable model for understanding the genetic alterations involved in head and neck squamous cell carcinoma (HNSCC) progression and for evaluating targeted therapies.
Research Applications
Chromosomal instability analysis11q13 amplification studiesATR-CHEK1 pathway investigationRadioresistance mechanismsHead and neck cancer progression
Key Characteristics
Chromosomal instability11q13 amplificationAneuploidyRadioresistanceCyclin D1 overexpression
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1855 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, buccal mucosa[UBERON:UBERON_0006956] |
Donor Information
| Age | 84 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001691_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg280Thr (c.839G>C) | Heterozygous | - | Unknown, PubMed=12872257 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
11,12
D16S539
11,12
D18S51
14,18.2
D19S433
14,15
D21S11
29,30
D2S1338
17,25
D3S1358
14,17
D5S818
11
D7S820
8,9
D8S1179
12,14
FGA
22,23
Penta D
13
Penta E
10,12
TH01
6,7
TPOX
9,11
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas.
Vlad A., Gollin S.M.
Genes Chromosomes Cancer 53:25-37(2014).
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.
Oral Oncol. 44:369-382(2008).
The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.
Gollin S.M.
Oral Oncol. 43:701-712(2007).