BC-2Homo sapiens (Human)Cancer cell line
Also known as: BC2
🤖 AI SummaryBased on 6 publications
Quick Overview
BC-2 is a cell line derived from primary effusion lymphoma, associated with Kaposi's sarcoma-associated herpesvirus (KSHV) and ...
Detailed Summary
BC-2 is a cell line established from a primary effusion lymphoma (PEL) case, characterized by its association with Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). These viral infections are common in PEL and contribute to the pathogenesis of the disease. BC-2 has been used in studies to investigate the genetic and molecular mechanisms underlying PEL, including the role of viral factors in cellular transformation and tumor development. Research on BC-2 has provided insights into the distinct gene expression profiles and genetic alterations associated with KSHV and EBV co-infection in PEL. The cell line is valuable for understanding the interactions between viral pathogens and host cells, as well as for developing targeted therapeutic strategies against PEL.
Research Applications
Viral infection studies (KSHV, EBV)Gene expression profilingMolecular mechanisms of PEL pathogenesisTherapeutic target identification
Key Characteristics
KSHV-positiveEBV-positiveAssociated with primary effusion lymphomaUsed in genomic and molecular studies
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1856 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 31 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Primary effusion lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Primary Effusion Lymphoma |
| OncoTree Code | PEL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-002478_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
11,12
D16S539
11,12
D18S51
13,14
D19S433
12,14
D21S11
29,30
D2S1338
18,19
D3S1358
14,18
D5S818
11,13
D7S820
8,9
D8S1179
14,16
FGA
22,24
Penta D
10,13
Penta E
13
TH01
7
TPOX
10,11
vWA
14,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Roy D., Sin S.-H., Damania B., Dittmer D.P.
Blood 118:e32-e39(2011).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin genes in human herpesvirus 8-associated primary effusion lymphoma.
Boulanger E., Marchio A., Hong S.-S., Pineau P.
Haematologica 94:1170-1174(2009).
Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.
Knowles D.M.
J. Virol. 79:1244-1251(2005).
Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).
Drexler H.G., Uphoff C.C., Gaidano G., Carbone A.
Leukemia 12:1507-1517(1998).
In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences.
Chang Y.
Blood 86:2708-2714(1995).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).