JeKo-1Homo sapiens (Human)Cancer cell line
Also known as: JEKO, JEKO1, Jeko1, JeKo 1, JEKO-1, Jeko-1
Quick Overview
JeKo-1 is a mantle cell lymphoma cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1865 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 78 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Mantle cell lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Mantle Cell Lymphoma |
| OncoTree Code | MCL |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000357_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Pro58Glnfs*65 (c.173delC) | Heterozygous | - | from parent cell line JeKo-1 |
| Gene deletion | TP53 | - | Homozygous | 2 out of 3 copies | from parent cell line HL-60 |
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
The LL-100 panel: 100 cell lines for blood cancer studies.";
MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
Sci. Rep. 9:8218-8218(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Screening human cell lines for viral infections applying RNA-Seq data analysis.
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
PLoS ONE 14:E0210404-E0210404(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Medeiros L.J., Ford R.J. Jr., Nomie K., Zhang L., Wang M.
Clin. Cancer Res. 24:3967-3980(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Rational targeted therapies to overcome microenvironment-dependent expansion of mantle cell lymphoma.
Touzeau C., Le Gouill S., Amiot M., Pellat-Deceunynck C.
Blood 128:2808-2818(2016).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736.
Damia G., Carrassa L.
Oncotarget 6:37229-37240(2015).
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
Isik E., Letai A.G., Lossos I.S.
Blood 126:1555-1564(2015).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
Moreau-Aubry A., Amiot M., Pellat-Deceunynck C.
Cytometry A 87:285-288(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
J. Virol. 89:713-729(2015).
Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection.
O'Connor O.A.
Leuk. Lymphoma 56:2114-2122(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
Martinez-Climent J.A.
Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011).
Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis.
Jares P.
Blood 109:5422-5429(2007).
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Martinez-Climent J.A.
Blood 109:271-280(2007).
Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines.
Colomer D., Miro R., Campo E.
Leuk. Res. 30:923-934(2006).
Characterization of 4 mantle cell lymphoma cell lines. Establishment of an in vitro study model.
Leventaki V., O'Connor S.L., Keating M.J., Lai R.
Arch. Pathol. Lab. Med. 127:424-431(2003).
Establishment and characterization of a mantle cell lymphoma cell line.
Jeon H.J., Kim C.W., Yoshino T., Akagi T.
Br. J. Haematol. 102:1323-1326(1998).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).