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KOPN-8Homo sapiens (Human)Cancer cell line

Also known as: KOPN8, Kopn-8

🤖 AI SummaryBased on 11 publications

Quick Overview

Human B-cell precursor leukemia cell line with FLT3 mutations

Detailed Summary

KOPN-8 is a human B-cell precursor leukemia cell line derived from a patient with acute lymphoblastic leukemia. It is characterized by the presence of FLT3 gene mutations, specifically tandem duplications in the FLT3 gene, which are associated with poor prognosis in leukemia patients. This cell line has been used in studies to investigate the role of FLT3 mutations in leukemogenesis and drug sensitivity. KOPN-8 is also part of the Cancer Cell Line Encyclopedia (CCLE) and has been utilized in research to identify genetic predictors of drug response and to study the molecular mechanisms underlying leukemia progression. The cell line is maintained in culture and has been used in multiple studies to explore the implications of FLT3 mutations in leukemia biology.

Research Applications

FLT3 mutation analysisLeukemogenesis studiesDrug sensitivity profilingGenomic and transcriptomic analysis

Key Characteristics

FLT3 gene tandem duplicationB-cell precursor lineageUsed in cancer research for drug response prediction

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1866
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

0

Age Category	Pediatric
Sex	Female
Subtype Features	KMT2A

Disease Information

Disease	B-lymphoblastic leukemia/lymphoma with t(v;11q23.3)
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3);KMT2A Rearranged
OncoTree Code	BLLKMT2A

DepMap Information

Source Type	DSMZ
Source ID	ACH-001106_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Gln (c.743G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=20575032
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757
Gene fusion	KMT2A	KMT2A-MLLT1, MLL-MLLT1, MLL-ENL	-	-	Unknown, PubMed=35354797, PubMed=31160637

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,12

D13S317

8,11

D16S539

9,11

D18S51

14,22

D19S433

13,14

D21S11

29

D2S1338

20,23

D3S1358

15,16

D5S818

9,11

D7S820

8,10

D8S1179

13,16

FGA

18,21

Penta D

12,13

Penta E

12,20

TH01

6,10

TPOX

8,11

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.

Drexler H.G., Quentmeier H., MacLeod R.A.F.

Leukemia 18:227-232(2004).

Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children.

Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.

Br. J. Haematol. 105:155-162(1999).

Establishment and characterization of human B cell precursor-leukemia cell lines.

Matsuo Y., Drexler H.G.

Leuk. Res. 22:567-579(1998).

Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.

Janssen J.W.G., Drexler H.G.

Leukemia 11:441-447(1997).

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

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