MEC-1Homo sapiens (Human)Cancer cell line

Also known as: MEC1

🤖 AI SummaryBased on 9 publications

MEC1/MEC2

Quick Overview

MEC1 and MEC2 are B-cell chronic lymphocytic leukemia cell lines derived from a patient in prolymphocytic transformation.

Detailed Summary

MEC1 and MEC2 are two cell lines established from a patient with B-chronic lymphocytic leukemia (B-CLL) undergoing prolymphocytic transformation. These cell lines were derived from peripheral blood samples and exhibit characteristics of CLL, including the expression of CD5, CD19, and CD20. They show distinct phenotypic differences, with MEC1 expressing CXCR4 and MEC2 expressing CD38. Both cell lines carry the same EBV strain but differ in their infection events and expression of EBV-encoded proteins. MEC1 and MEC2 have been used in studies to understand the progression of CLL to prolymphocytic leukemia and the role of EBV in this process. They are valuable tools for investigating the molecular mechanisms underlying CLL and its transformation.

Research Applications

Study of B-cell chronic lymphocytic leukemia progressionInvestigation of EBV infection in CLLAnalysis of clonal evolution in leukemiaCharacterization of cell surface markers in CLL

Key Characteristics

Express CD5, CD19, and CD20Differentiated by CD38 and CXCR4 expressionCarry EBV with distinct infection eventsRepresent different stages of CLL progression

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1870
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	61
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	B-cell chronic lymphocytic leukemia
Lineage	Lymphoid
Subtype	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
OncoTree Code	CLLSLL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000405_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gln317Profs*20 (c.949dupC) (c.949_950insC)	Homozygous	-	Unknown
Gene fusion	HTRA1	R3HCC1L-HTRA1	-	-	PubMed=31160637

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D10S1248

D12S391

D13S317

11,12

D16S539

9,11

D18S51

D19S433

12,14

D1S1656

15,17

D21S11

27,29

D22S1045

15,16

D2S1338

16,19

D2S441

D3S1358

15,19

D5S818

10,12

D7S820

7,11

D8S1179

13,15

DYS391

FGA

21,25

Penta D

11,17

Penta E

10,12

TH01

6,8

TPOX

8,11

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The MEC1 and MEC2 lines represent two CLL subclones in different stages of progression towards prolymphocytic leukemia.

Koroknai A., Minarovits J., Klein G., Klein E.

PLoS ONE 9:E106008-E106008(2014).

DOI PubMed PMC

Molecular characterization of neoplastic and normal 'sister' lymphoblastoid B-cell lines from chronic lymphocytic leukemia.

Jurlander J., Klein E., Weit N., Herling M., Rosenquist R., Rosen A.

Leuk. Lymphoma 54:1769-1779(2013).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.

Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.

J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation.

Caligaris-Cappio F.

Leuk. Res. 23:127-136(1999).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

tcpaportal.org