MUTZ-5Homo sapiens (Human)Cancer cell line

Also known as: Menschliche Und Tierische Zellkulture-5, MUTZ5, Mutz-5

🤖 AI SummaryBased on 5 publications

Quick Overview

MUTZ-5 is a B cell precursor acute lymphoblastic leukemia cell line with t(12;13) translocation.

Detailed Summary

MUTZ-5 is a human B cell precursor acute lymphoblastic leukemia cell line established from the peripheral blood of a 26-year-old male patient at relapse. It carries a t(12;13) translocation, which is a chromosomal abnormality associated with certain types of leukemia. The cell line is characterized by its immunophenotype, which includes markers typical of precursor B cells, such as CD10, CD19, CD20, and CD22. MUTZ-5 is used in research for studying the molecular mechanisms of leukemia, particularly focusing on the effects of the t(12;13) translocation. It serves as a model system for investigating the genetic and molecular changes associated with this specific chromosomal rearrangement, contributing to the understanding of leukemia pathogenesis and potential therapeutic targets.

Research Applications

Study of chromosomal translocations in leukemiaInvestigation of molecular mechanisms of B cell precursor ALLModel system for t(12;13) translocation research

Key Characteristics

Carries t(12;13) translocationExpresses B cell precursor markersUsed for leukemia research

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1873
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	26
Age Category	Adult
Sex	Male
Subtype Features	CRLF2 Ph-like

Disease Information

Disease	Precursor B-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma, BCR-ABL1 Like
OncoTree Code	BLLBCRABL1L

DepMap Information

Source Type	DSMZ
Source ID	ACH-000492_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

8,9

D13S317

10,12

D16S539

D18S51

14,15

D19S433

14,17

D21S11

29,31.2

D2S1338

19,21

D3S1358

D5S818

D7S820

D8S1179

10,11

FGA

19,23

Penta D

10,11

Penta E

13,17

TH01

TPOX

8,11

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

DOI PubMed

Establishment of the B cell precursor acute lymphoblastic leukemia cell line MUTZ-5 carrying a (12:13) translocation.

Coignet L.J.A., Dyer M.J.S., Drexler H.G.

Leukemia 15:1471-1474(2001).

DOI PubMed

Establishment of the B-cell precursor-acute lymphoblastic leukemia cell line MUTZ-5 carrying a (12:13) translocation.

Coignet L.J.A., Drexler H.G.

(In book chapter) Acute leukemias IX. Haematology and blood transfusion, Vol. 41; Hiddemann W., Haferlach T., Unterhalt M., Buechner T., Ritter J. (eds.); pp.15-18; Springer; Berlin; Germany (2003).

DOI