NU-DUL-1Homo sapiens (Human)Cancer cell line

Also known as: NUDUL1, NUDUL-1

🤖 AI SummaryBased on 7 publications

Quick Overview

Human cancer cell line for research on genetic and molecular mechanisms.

Detailed Summary

NU-DUL-1 is a human cancer cell line derived from an unspecified tissue and disease. It is used in research to study genetic and molecular mechanisms of cancer. The cell line is part of various genomic and transcriptomic studies, contributing to understanding of cancer biology and drug sensitivity. Research on this cell line includes analysis of gene expression, mutations, and response to therapeutic agents. The cell line's characteristics are part of comprehensive datasets like the Cancer Cell Line Encyclopedia (CCLE) and other genomic studies, providing insights into cancer heterogeneity and potential therapeutic targets.
Generated on 6/17/2025

Basic Information

Database IDCVCL_1877
SpeciesHomo sapiens (Human)
Tissue SourceCerebrospinal fluid[UBERON:UBERON_0001359]

Donor Information

Age43
Age CategoryAdult
SexMale
Racecaucasian

Disease Information

DiseaseDiffuse large B-cell lymphoma
LineageLymphoid
SubtypeActivated B-cell Type
OncoTree CodeABC

DepMap Information

Source TypeDSMZ
Source IDACH-000287_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Arg248Gln (c.743G>A)UnspecifiedSomatic mutation acquired during proliferationPubMed=20575032
MutationSimpleTP53p.Val143Met (c.427G>A)Heterozygous-Unknown, Unknown
MutationSimpleKRASp.Asp119Asn (c.355G>A)Heterozygous-Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11,12
D13S317
8,13
D16S539
11,13
D18S51
13,14
D19S433
14,15
D21S11
28,32.2
D2S1338
24,25
D3S1358
14,16
D5S818
12,14
D7S820
11,13
D8S1179
13
FGA
22
Penta D
9,13
Penta E
10,13
TH01
9,9.3
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.

Marra M.A.

Blood 122:1256-1265(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.

Robetorye R.S., Aguiar R.C.T.

Blood 113:6681-6690(2009).

Use of novel chemical supplements in the establishment of three human malignant lymphoma cell lines (NU-DHL-1, NU-DUL-1, and NU-AMB-1) with chromosome 14 translocations.

Epstein A.L., Variakojis D., Berger C.S., Kaiser-McCaw Hecht B.

Int. J. Cancer 35:619-627(1985).