ONCO-DG-1Homo sapiens (Human)Cancer cell line
Also known as: ONCODG1, ONCO-DG1, ONCO-DG 1
🤖 AI SummaryBased on 4 publications
Quick Overview
Human cell line for cancer research, unknown tissue and disease origin.
Detailed Summary
ONCO-DG-1 is a human cell line with unknown tissue and disease origins. It is used in cancer research, particularly in studies evaluating genomic profiles and cell line models for tumours. Research indicates that some commonly used cell lines may not accurately represent specific cancer subtypes, highlighting the importance of selecting appropriate models for in vitro studies. The cell line's genomic characteristics are part of ongoing efforts to improve the accuracy of cancer research models.
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1882 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Donor Information
| Age | 60 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | High grade ovarian serous adenocarcinoma |
|---|---|
| Lineage | Ovary/Fallopian Tube |
| Subtype | High-Grade Serous Ovarian Cancer |
| OncoTree Code | HGSOC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000013_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Gln (c.743G>A) | Unspecified | Somatic mutation acquired during proliferation | PubMed=20575032 |
| MutationSimple | PIK3R1 | c.1746-2A>T | Heterozygous | Splice acceptor mutation | from parent cell line OVCAR-3 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
12
D16S539
12
D18S51
13
D19S433
14,17
D21S11
29,31.2
D2S1338
17,21
D3S1358
17,18
D5S818
11,12
D7S820
10
D8S1179
8,15
FGA
21
Penta D
12,13
Penta E
7,13
TH01
9,9.3
TPOX
8
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Evaluating cell lines as tumour models by comparison of genomic profiles.
Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.
Nat. Commun. 4:2126.1-2126.10(2013).
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Freshney R.I.
Int. J. Cancer 127:1-8(2010).
p73 tumor-suppressor activity is impaired in human thyroid cancer.";
Vigneri P.
Cancer Res. 63:5829-5837(2003).