RC-K8Homo sapiens (Human)Cancer cell line

Also known as: Rck8, RCK8, RCK-8

🤖 AI SummaryBased on 11 publications

Quick Overview

RC-K8 is a human B-cell lymphoma cell line with 11q23 translocations, used in cancer research.

Detailed Summary

RC-K8 is a human B-cell lymphoma cell line characterized by 11q23 translocations, which are commonly associated with aggressive hematological malignancies. This cell line has been utilized in studies investigating the genetic and molecular mechanisms underlying lymphomagenesis, particularly focusing on the MLL gene and its role in chromosomal translocations. RC-K8 is also used to study the effects of various therapeutic agents and to understand the genetic heterogeneity in lymphomas. The cell line has been part of research on gene expression profiles, copy number variations, and the identification of potential therapeutic targets. Its utility in understanding the pathogenesis of lymphomas and in drug development is well-documented in multiple studies.

Research Applications

Genetic and molecular mechanisms of lymphomagenesisMLL gene and chromosomal translocationsTherapeutic agent effectsGene expression profilesCopy number variationsTherapeutic target identification

Key Characteristics

11q23 translocationsB-cell lineageUsed in cancer research

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1883
Species	Homo sapiens (Human)
Tissue Source	Peritoneal effusion[UBERON:UBERON_0001268]

Donor Information

Age	55
Age Category	Adult
Sex	Male

Disease Information

Disease	Diffuse large B-cell lymphoma
Lineage	Lymphoid
Subtype	Germinal Center B-Cell Type
OncoTree Code	GCB

DepMap Information

Source Type	DSMZ
Source ID	ACH-001638_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,13

D13S317

D16S539

D18S51

16,18.3

D19S433

13,14

D21S11

28,30

D2S1338

19,23

D3S1358

15,16

D5S818

10,11

D7S820

10.3,12

D8S1179

14,15

FGA

23.2,24

Penta D

9,11

Penta E

TH01

TPOX

vWA

18,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.

Isik E., Letai A.G., Lossos I.S.

Blood 126:1555-1564(2015).

DOI PubMed PMC

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Genetic heterogeneity of diffuse large B-cell lymphoma.";

Dunson D.B., Dave S.S.

Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013).

DOI PubMed PMC

Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.

Robetorye R.S., Aguiar R.C.T.

Blood 113:6681-6690(2009).

DOI PubMed PMC

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.

Martinez-Climent J.A.

Blood 109:271-280(2007).

DOI PubMed

Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.

Aizawa Y., Ueda R., Seto M.

Jpn. J. Cancer Res. 89:712-718(1998).

DOI PubMed PMC

Establishment of a new human lymphoma line that secretes plasminogen activator.

Kubonishi I., Niiya K., Miyoshi I.

Jpn. J. Cancer Res. 76:12-15(1985).

DOI PubMed

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

Rowley J.D., Diaz M.O.

Proc. Natl. Acad. Sci. U.S.A. 88:10735-10739(1991).

DOI PubMed PMC

Phenotypic and genotypic characterization of 14 leukemia and lymphoma cell lines with 11q23 translocations.

Ueda R., Nakazawa S.

Leuk. Res. 16:1155-1163(1992).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

tcpaportal.org