Ri-1Homo sapiens (Human)Cancer cell line

Also known as: Riva, RIVA, RI1, RI-1

🤖 AI SummaryBased on 12 publications

Quick Overview

Ri-1 is a human leukemia/lymphoma cell line with potential applications in cancer research.

Detailed Summary

Ri-1 is a human leukemia/lymphoma cell line that has been characterized in multiple studies. It is derived from a patient with B-cell lymphoma/leukemia and has been used in research to study genetic and molecular mechanisms of cancer. The cell line exhibits specific chromosomal abnormalities, including a 14q+ abnormality, which is associated with certain types of lymphomas. Ri-1 has been utilized in studies involving gene expression profiling, protein analysis, and drug sensitivity testing. It is part of a panel of cell lines used to investigate the pathogenesis of B-cell malignancies and to develop targeted therapies. The cell line's genetic and phenotypic characteristics make it a valuable tool for understanding the molecular basis of leukemia and lymphoma.

Research Applications

Cancer researchGenetic and molecular studiesDrug sensitivity testingGene expression profiling

Key Characteristics

14q+ abnormalityB-cell lineageUsed in studies of B-cell malignancies

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1885
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	57
Age Category	Adult
Sex	Female

Disease Information

Disease	Diffuse large B-cell lymphoma
Lineage	Lymphoid
Subtype	Activated B-cell Type
OncoTree Code	ABC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000398_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Glu294Ter (c.880G>T)	Unspecified	-	PubMed=12872257
MutationSimple	TP53	p.Lys132Arg (c.395A>G)	Unspecified	-	PubMed=34732238

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

9,14

D16S539

11,12

D18S51

D19S433

14,15

D21S11

D2S1338

17,23

D3S1358

D5S818

D7S820

9,13

D8S1179

10,13

FGA

22,25

Penta D

11,12

Penta E

7,11

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.

Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.

Leuk. Lymphoma 57:1015-1020(2016).

DOI PubMed

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.

Martinez-Climent J.A.

Blood 109:271-280(2007).

DOI PubMed

Frameshift mutations of the hMSH6 gene in human leukemia cell lines.

Hirai H.

Jpn. J. Cancer Res. 89:33-39(1998).

DOI PubMed PMC

The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.

Quentmeier H., Drexler H.G.

Leukemia 10:142-149(1996).

PubMed

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

DOI PubMed

Establishment and characterization of three new malignant lymphoid cell lines.

White H., Catovsky D., Foroni L., Luzzatto L., Goldman J.M.

Int. J. Cancer 39:89-93(1987).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

tcpaportal.org