U-2940Homo sapiens (Human)Cancer cell line
Also known as: U2940
🤖 AI SummaryBased on 4 publications
Quick Overview
Human B-cell line derived from diffuse large B-cell lymphoma following Hodgkin lymphoma.
Detailed Summary
U-2940 is a human B-cell line established from a diffuse large B-cell lymphoma that developed in a patient 8 months after the diagnosis of nodular sclerosis Hodgkin lymphoma. The cell line exhibits characteristics of Hodgkin-Reed-Sternberg (HRS) cells, including irregular nuclei and abundant cytoplasm. It is negative for CD30 and T-cell markers, and shows a mature B-cell phenotype with strong expression of CD19 and CD20. U-2940 has been used in studies related to the molecular mechanisms of Hodgkin lymphoma and its association with B-cell malignancies. The cell line has been characterized for chromosomal abnormalities and microsatellite instability, which are relevant to lymphoma research.
Research Applications
Molecular analysis of Hodgkin lymphomaStudy of B-cell malignanciesChromosomal abnormalities in lymphomasMicrosatellite instability in cancer
Key Characteristics
Mature B-cell phenotypeCD19 and CD20 expressionIrregular nuclear morphologyNegative for CD30 and T-cell markers
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1897 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Additional Information |
|
|---|---|
| Age | 18 |
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Diffuse large B-cell lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Diffuse Large B-Cell Lymphoma, NOS |
| OncoTree Code | DLBCLNOS |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001678_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
8,10
D16S539
10,12
D18S51
12,17
D19S433
14,15
D21S11
29
D2S1338
19
D3S1358
16,17
D5S818
11,12
D7S820
10,12
D8S1179
12
FGA
24,26
Penta D
14,15
Penta E
7,14
TH01
7,9.3
TPOX
8,12
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
The LL-100 panel: 100 cell lines for blood cancer studies.";
MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
Sci. Rep. 9:8218-8218(2019).
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Biol. Chem. 399:511-523(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation.
Zaborski M., Drexler H.G.
Oncotarget 7:63456-63465(2016).