U-2973Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 3 publications
Quick Overview
U-2973 is a B-cell line with t(14;18) and MYC translocations, used in lymphoma research.
Detailed Summary
U-2973 is a B-cell lymphoma cell line established from a patient with a mature B-cell leukemia exhibiting concurrent t(14;18) and MYC translocations. The cell line displays a mature B-cell phenotype, with expression of MYC and BCL2, and is characterized by a complex karyotype. It has been used in studies to understand the molecular mechanisms of double-hit lymphomas and their aggressive clinical behavior. The cell line was deposited at the German Resource Centre for Biological Material (DSMZ) and tested negative for mycoplasma.
Research Applications
Double-hit lymphoma researchMYC and BCL2 translocation studiesLymphoma molecular mechanisms
Key Characteristics
t(14;18) translocationMYC translocation to non-IG partnerComplex karyotypeMature B-cell phenotype
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1898 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 42 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | High grade B-cell lymphoma with MYC and/or BCL2 and/or BCL6 rearrangement |
|---|---|
| Lineage | Lymphoid |
| Subtype | High-Grade B-Cell Lymphoma, with MYC and BCL2 and/or BCL6 Rearrangements |
| OncoTree Code | HGBCLMYCBCL2 |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001679_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | IRAG2 | MYC-IRAG2, MYC-LRMP | - | - | PubMed=23171647 |
| Gene fusion | BCL2 | IGH-BCL2 | - | - | from parent cell line SU-DHL-4 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11
D13S317
10,11
D16S539
11,13
D18S51
12,16
D19S433
13,14
D21S11
29,32.2
D2S1338
23,24
D3S1358
15,18
D5S818
11,12
D7S820
10,11
D8S1179
13
FGA
21,22
Penta D
12,13
Penta E
16
TH01
7,9.3
TPOX
8
vWA
17,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Leuk. Lymphoma 57:1015-1020(2016).
Sequence based analysis of U-2973, a cell line established from a double-hit B-cell lymphoma with concurrent MYC and BCL2 rearrangements.
Sjoblom T., Cavelier L.
BMC Res. Notes 5:648.1-648.4(2012).