UPCI-SCC-090Homo sapiens (Human)Cancer cell line
Also known as: SCC90, SCC090, UPCISCC090, UPCI-SCC090, UPCI:SCC90, UPCI:SCC090, UPCI-SCC-90
Quick Overview
Human head and neck squamous cell carcinoma cell line with HPV16 integration
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1899 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, tongue[UBERON:UBERON_0001723] |
Donor Information
| Age | 46 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral tongue |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001227_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Genotyping and characterization of HPV status, hypoxia, and radiosensitivity in 22 head and neck cancer cell lines.
Gottgens E.-L., Ansems M., Leenders W.P.J., Bussink J., Span P.N.
Cancers (Basel) 13:1069.1-1069.12(2021).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.
Bier H., Brakenhoff R.H., Bradford C.R., Carey T.E.
Head Neck 39:840-852(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
Oncotarget 5:8906-8923(2014).
Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma.
Doi K., Nakagawa K.
Cancer Med. 2:933-941(2013).
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Symer D.E., Gillison M.L.
Genome Res. 24:185-199(2014).
Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma.
Teschendorff A.E., Boshoff C., Beck S.
Genome Med. 5:15.1-15.16(2013).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Yarbrough W.G., Whigham A., Brown B., Roach M., Slebos R.J.C.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007).
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.
Oral Oncol. 44:369-382(2008).