WILL-1Homo sapiens (Human)Cancer cell line
Also known as: WILL1
🤖 AI SummaryBased on 1 publications
Quick Overview
WILL-1 is a CD5 and CD10 double-positive B-cell line with complex translocations.
Detailed Summary
WILL-1 is a mature B-cell line established from a CD5 and CD10 double-positive diffuse large B-cell lymphoma patient. The cell line exhibits a complex 8q24 translocation involving 14q32 and 6q27, as identified through spectral karyotype (SKY) and fluorescence in situ hybridization (FISH) analyses. WILL-1 cells are positive for CD5, CD10, CD19, and CD20, and express BCL6 protein and MUM1/IRF4 mRNA. This cell line is valuable for studying the pathogenesis of CD5 and CD10 double-positive diffuse large B-cell lymphoma and for molecular cloning of unique translocation breakpoints on 14q32, 8q24, and a novel gene on 6q27.
Research Applications
Analysis of CD5 and CD10 double-positive diffuse large B-cell lymphoma pathogenesisMolecular cloning of translocation breakpoints on 14q32 and 8q24Investigation of complex chromosomal translocations involving 6q27
Key Characteristics
CD5 and CD10 double-positiveExpresses BCL6 proteinExpresses MUM1/IRF4 mRNAComplex 8q24 translocation involving 14q32 and 6q27
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1900 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 82 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Diffuse large B-cell lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Diffuse Large B-Cell Lymphoma, NOS |
| OncoTree Code | DLBCLNOS |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-002678_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12,13
D13S317
9,11
D16S539
9,11
D18S51
14,22
D19S433
13,14
D21S11
28,32.2
D2S1338
19
D3S1358
15,16
D5S818
10
D7S820
11,12
D8S1179
14
FGA
22
Penta D
9,13
Penta E
12
TH01
9
TPOX
11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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